Results 51 to 60 of about 2,149,929 (236)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Microscopic Multiple Fatigue Crack Simulation and Macroscopic Damage Evolution of Concrete Beam
Applied Sciences, 2019 Microcracks in concrete can coalesce into larger cracks that further propagate under repetitive load cycles. Complex process of crack formation and growth are essentially involved in the failure mechanism of concrete.
Baijian Wu +3 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Continuum Damage-Healing Mechanics with Introduction to New Healing Variables
, 2012 In this study, damage and healing mechanisms are discussed in detail with special emphasis given on two new healing variables. They are introduced in terms of healing variable based on area and healing variable based on elastic stiffness.
George Voyiadjis
core +1 more source
A continuum damage mechanics-based approach for the high cycle fatigue behavior of metallic polycrystals [PDF]
, 2018 International audiencePolycrystalline elasto-plasticity models provide a general framework for investigating the effect of microstructural heterogeneities (e.g. grains, inclusions, pores) on the high cycle fatigue behavior of metallic materials.
Mareau, Charles, Morel, Franck
core +1 more source
Anisotropic Elastoplastic Damage Mechanics Method to Predict Fatigue Life of the Structure
Advances in Materials Science and Engineering, 2016 New damage mechanics method is proposed to predict the low-cycle fatigue life of metallic structures under multiaxial loading. The microstructure mechanical model is proposed to simulate anisotropic elastoplastic damage evolution.
Hualiang Wan, Qizhi Wang, Zheng Zhang
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Acta Scientiarum: Technology, 2009 In this work, non-linear analyses of reinforced concrete plates are performed by using a BEM formulation, based on Kirchhoff’s theory, which has already proved to be a robust technique to deal with plate problems.
Gabriela Rezende Fernandes +2 more
doaj +1 more source