Results 61 to 70 of about 2,149,929 (236)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
A Generalized Hypothesis of Elastic Energy Equivalence in Continuum Damage Mechanics
Engineering Transactions, 2017 A new generalized hypothesis of elastic energy equivalence is proposed. The proposed generalized hypothesis is inclusive of all the existing different hypotheses of equivalence in continuum damage mechanics and all are obtained as special cases ...
George Z. VOYIADJIS, Peter I. KATTAN
doaj +1 more source
Modelling of brittle damage nucleation by means of ca [PDF]
Computer Methods in Materials Science, 2007 The description of damage nucleation in metals subjected to creep conditions, on the level of material structure, is proposed. In classical approach of mechanics it is achieved by introducing scalar (or tensorial) parameter called damage variable and ...
Krzysztof Nowak
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Damage evaluation and damage localization of rock
, 2004 Knowledge of damage accumulation and corresponding failure evolution are prerequisite for effective maintenance of civil engineering so as to avoid disaster. Based on statistical mesoscopic damage mechanics, it was revealed that there are three stages in
Ma SP +5 more
core +1 more source
Some Models of Mechanics of Local Damage
Механика машин, механизмов и материалов, 2011 The technique for determination of local damage of complexly loaded mechanical system based on model of the deformable rigid body with dangerous volume is considered. Calculation of damage contact interaction is made.
O.M. Yelovoy
doaj
Zhongguo Jianchuan YanjiuLarge ships and submarines are the main equipment and mobile platforms supporting three-dimensional naval space operations. However, with the increasing damage power and strike accuracy of warheads, plus the diversity of destroying elements, their living
Ying LI +13 more
doaj +1 more source
Evaluation of fatigue life of polycrystalline structural alloys
MATEC Web of Conferences, 2018 A mathematical model describing the processes of elastoplastic deformation and damage accumulation under low-cycle loading has been developed, based on the viewpoint of mechanics of damaged media (MDM). The MDM model consists of three interrelated parts:
Volkov Ivan A. +2 more
doaj +1 more source
Modelling the Damage of Structural Components with Macrostructure Defects
Metals, 2019 The article presents a numerical analysis of the process of damage of structural steel, the scope of which encompassed the estimation of the time to failure of a structural component.
Paweł Grzegorz Kossakowski
doaj +1 more source