Results 61 to 70 of about 60,909 (219)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Metals, 2015 In this study, fatigue crack growth rates (FCGR) of 7% nickel steel at room and cryogenic temperatures were evaluated using damage-coupled finite element analysis (FEA).
Seul-Kee Kim +6 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
SURVEY OF MODERN TRENDS IN ANALYSIS OF CONTINUUM DAMAGE MECHANICS
TASK Quarterly, 2006 A brief review of the damage mechanics literature is given. As this area of scientific research is very modern, the authors have restricted themselves to about 100 most important books and papers.
ANDRZEJ AMBROZIAK, PAWEŁ KŁOSOWSKI
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Damage Mechanics of Biological Tissues in Relation to Viscoelasticity. [PDF]
J Biomech Eng, 2023 Ateshian GA +5 more
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Nanotechnology Reviews, 2019 Interfacial bonding between the fibers and matrix plays a large role in mechanical properties of composites. In this paper, poly(oxypropylene) diamines (D400) and graphene oxide (GO) nanoparticles were grafted on the desized 3D multi axial warp knitted ...
Zuo Hong-mei +3 more
doaj +1 more source
A Phase-Field Approach to Continuum Damage Mechanics. [PDF]
Materials (Basel), 2022 Morro A.
europepmc +1 more source