Results 61 to 70 of about 436,032 (358)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Anisotropic Elastoplastic Damage Mechanics Method to Predict Fatigue Life of the Structure

Advances in Materials Science and Engineering, 2016
New damage mechanics method is proposed to predict the low-cycle fatigue life of metallic structures under multiaxial loading. The microstructure mechanical model is proposed to simulate anisotropic elastoplastic damage evolution.
Hualiang Wan, Qizhi Wang, Zheng Zhang
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Non-linear analysis of reinforced concrete plates by the boundary element method and continuum damage mechanics - DOI: 10.4025/actascitechnol.v31i1.348

Acta Scientiarum: Technology, 2009
In this work, non-linear analyses of reinforced concrete plates are performed by using a BEM formulation, based on Kirchhoff’s theory, which has already proved to be a robust technique to deal with plate problems.
Gabriela Rezende Fernandes, Daniele Araújo, José Júlio de Cerqueira Pituba   +2 more
doaj   +1 more source

Preliminary analysing of experimental data for the development of high Cr Alloy Creep damage Constitutive Equations [PDF]

, 2012
This conference paper presents the current research of preliminary analysing of experimental data for the development of high Cr Alloy Creep damage Constitutive Equations (such as P91 alloy). Firstly, it briefly introduces the background of general creep
An, Lili, Lu, Zhongyu, Xu, Donglai, Xu, Qiang   +3 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A Generalized Hypothesis of Elastic Energy Equivalence in Continuum Damage Mechanics

Engineering Transactions, 2017
A new generalized hypothesis of elastic energy equivalence is proposed. The proposed generalized hypothesis is inclusive of all the existing different hypotheses of equivalence in continuum damage mechanics and all are obtained as special cases ...
George Z. VOYIADJIS, Peter I. KATTAN
doaj   +1 more source

Influence of woven ply degradation on fatigue crack growth in thin notched composites under tensile loading [PDF]

, 2010
This paper deals with the fatigue of the through the-thickness crack propagation in thin notched composite laminates made of two glass woven plies. It highlights the different crack growths between warp and weft directions of the woven ply.
Barrau, Jean-Jacques, Bizeul, Matthieu, Bouvet, Christophe, Cuenca, Rémy   +3 more
core   +3 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source