Results 41 to 50 of about 79,411 (313)

A mechanistic approach to the Kitagawa-Takahashi diagram using a multiaxial probabilistic framework [PDF]

open access: yes, 2013
The aim of this paper is to propose a flexible multiaxial modelling framework that is capable of combining two fatigue damage mechanisms so as to continuously describe the Kitagawa-Takahashi diagram.
PESSARD, Etienne   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Fuzzy stochastic damage mechanics (FSDM) based on fuzzy auto-adaptive control theory

open access: yesWater Science and Engineering, 2012
In order to fully interpret and describe damage mechanics, the origin and development of fuzzy stochastic damage mechanics were introduced based on the analysis of the harmony of damage, probability, and fuzzy membership in the interval of [0,1].
Ya-jun Wang   +3 more
doaj   +1 more source

A Nonlinear Creep-damage Constitutive Model of Mudstone Based on the Fractional Calculus Theory [PDF]

open access: yesJournal of Petroleum Science and Technology, 2017
During the flood development in an oil field, the creep characteristic of mudstone is one of the important factors causing casing damage. In this study, based on the theory of fractional order differential and taking into account the creep damage ...
Zhang Jun, Zeng Jia
doaj   +1 more source

Experimental and Numerical Investigation of Ballistic Resistance of Polyurea-Coated Aluminum Plates under Projectile Impacts

open access: yesCrystals, 2023
The effects of the spraying thickness and the position on the response of aluminum plates under impact loading were studied. The impact tests and numerical simulation were conducted for the penetration process of polyurea-coated 2024 aluminum plates with
Chenglong He   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Application of damage mechanics in percussive drilling modelling [PDF]

open access: yes, 2005
A stationary-periodic quasi-static model of rock percussive deep drilling is introduced. First, an auxiliary problem of stationary indentation of a rigid indentor is considered.
Mikhailov, SE   +3 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A damage model of mechanical behavior of porous materials: Application to sandstone [PDF]

open access: yes, 2018
In this work, a multiscale model based on the Fast Fourier Transform (FFT) technique is applied to describe the mechanical behavior of porous materials.
Cao, Y. J.   +3 more
core   +3 more sources

Research in the development of finite element software for creep damage analysis [PDF]

open access: yes, 2013
This paper reports the development of finite element software for creep damage analysis. Creep damage deformation and failure of high temperature structure is a serious problem for power generation and it is even more technically demanding under the ...
Xu, Qiang, Liu, Dezheng, Lu, Zhongyu
core  

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