Results 41 to 50 of about 60,909 (219)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Microscopic Multiple Fatigue Crack Simulation and Macroscopic Damage Evolution of Concrete Beam
Applied Sciences, 2019 Microcracks in concrete can coalesce into larger cracks that further propagate under repetitive load cycles. Complex process of crack formation and growth are essentially involved in the failure mechanism of concrete.
Baijian Wu +3 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Anisotropic Elastoplastic Damage Mechanics Method to Predict Fatigue Life of the Structure
Advances in Materials Science and Engineering, 2016 New damage mechanics method is proposed to predict the low-cycle fatigue life of metallic structures under multiaxial loading. The microstructure mechanical model is proposed to simulate anisotropic elastoplastic damage evolution.
Hualiang Wan, Qizhi Wang, Zheng Zhang
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Acta Scientiarum: Technology, 2009 In this work, non-linear analyses of reinforced concrete plates are performed by using a BEM formulation, based on Kirchhoff’s theory, which has already proved to be a robust technique to deal with plate problems.
Gabriela Rezende Fernandes +2 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
A Generalized Hypothesis of Elastic Energy Equivalence in Continuum Damage Mechanics
Engineering Transactions, 2017 A new generalized hypothesis of elastic energy equivalence is proposed. The proposed generalized hypothesis is inclusive of all the existing different hypotheses of equivalence in continuum damage mechanics and all are obtained as special cases ...
George Z. VOYIADJIS, Peter I. KATTAN
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Modelling of brittle damage nucleation by means of ca [PDF]
Computer Methods in Materials Science, 2007 The description of damage nucleation in metals subjected to creep conditions, on the level of material structure, is proposed. In classical approach of mechanics it is achieved by introducing scalar (or tensorial) parameter called damage variable and ...
Krzysztof Nowak
doaj +1 more source