Results 81 to 90 of about 60,909 (219)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Numerical Investigation of Prefabricated Utility Tunnels Composed of Composite Slabs with Spiral Stirrup-Constrained Connection Based on Damage Mechanics. [PDF]
Materials (Basel), 2022 Wang Q, Gong G, Hao J, Bao Y.
europepmc +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Avaliação de deflexões em estruturas de concretoarmado utilizando mecânica do dano
Revista IBRACON de Estruturas e MateriaisEste trabalho visa apresentar uma contribuição sobre uma proposta de abordagem para o cálculo de deslocamentos em estruturas de concreto armado em regime de serviço, sendo restrito o estudo ao caso de concretos C20 a C35.
J. J. C. Pituba, R. G. Delalibera
doaj +1 more source
On the use of constrained reactive mixtures of solids to model finite deformation isothermal elastoplasticity and elastoplastic damage mechanics. [PDF]
J Mech Phys Solids, 2021 Zimmerman BK +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
A Generalized Interpolation Material Point Method for Shallow Ice Shelves. 2: Anisotropic Nonlocal Damage Mechanics and Rift Propagation. [PDF]
J Adv Model Earth Syst, 2021 Huth A, Duddu R, Smith B.
europepmc +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source