Results 81 to 90 of about 2,149,929 (236)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Damage Mechanics of Biological Tissues in Relation to Viscoelasticity. [PDF]

J Biomech Eng, 2023
Ateshian GA, Kroupa KR, Petersen CA, Zimmerman BK, Maas SA, Weiss JA.   +5 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The multiscale enhancement of mechanical properties of 3D MWK composites via poly(oxypropylene) diamines and GO nanoparticles

Nanotechnology Reviews, 2019
Interfacial bonding between the fibers and matrix plays a large role in mechanical properties of composites. In this paper, poly(oxypropylene) diamines (D400) and graphene oxide (GO) nanoparticles were grafted on the desized 3D multi axial warp knitted ...
Zuo Hong-mei, Li Dian-sen, Hui David, Jiang Lei   +3 more
doaj   +1 more source

A Phase-Field Approach to Continuum Damage Mechanics. [PDF]

Materials (Basel), 2022
Morro A.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

An Entropy Based Low-Cycle Fatigue Life Prediction Model for Solder Materials

Entropy, 2017
Fatigue damage is an irreversible progression which can be represented by the entropy increase, and it is well known that the second law of thermodynamics can describe an irreversible process.
Jundong Wang, Yao Yao
doaj   +1 more source

Parametric Damage Mechanics Empowering Structural Health Monitoring of 3D Woven Composites. [PDF]

Sensors (Basel), 2023
Jacot M, Champaney V, Chinesta F, Cortial J.   +3 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Intelligent Models of Wear-Fatigue Damage and Fracture Mechanics

Механика машин, механизмов и материалов
Artificial intelligence technologies are considered in comparison with mathematical modeling using the examples of a number of critical purpose technical systems studied in tribo-fatigue.
Sergei S. Sherbakov
doaj   +1 more source