Results 81 to 90 of about 79,411 (313)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
MECHANISM OF ALCOHOLIC TESTICULAR DAMAGE
The Japanese Journal of Urology, 1992 To observe the mechanism of alcoholic testicular damage, in a previous experiment we used weanling male SD rats aged 45 days, weighing about 200 g, and fed a liquid diet (Lieber's) containing 5% ethanol. The latter accounted for 36% of total caloric intake for 7 weeks, but did not result in testicular atrophy.
Shirai, Takashi, Ikemoto, Isao
openaire +3 more sources
Experimental characterization and numerical modeling of micromechanical damage under different stress states [PDF]
, 2013 The use of HSLA steels for the manufacture of automotive components is interesting from an engineering point of view. This family of steels, while possessing high strength, also has good formability and can be used in forming manufacturing processes.
GERMAIN, Guénaël +3 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Some Models of Mechanics of Local Damage
Механика машин, механизмов и материалов, 2011 The technique for determination of local damage of complexly loaded mechanical system based on model of the deformable rigid body with dangerous volume is considered. Calculation of damage contact interaction is made.
O.M. Yelovoy
doaj
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
A Continuum Damage Mechanics Model for Multiaxial Low Cycle Fatigue Life [PDF]
, 2000 A continuum damage mechanics model for low cycle fatigue failure of initially isotropic materials under multiaxial loading is presented. The expression for the equivalent strain in the fatigue damage evolution equation contains the three material ...
ITOH, Takamoto +2 more
core
Effects of damage distribution on evolution [PDF]
, 1997 Recent micromechanically inspired phenomenological theories using internal state variable (ISV) representations of damage have been used to predict the thermomechanical behavior of microcracked solids.
McDowell, David L., +2 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Metals, 2015 In this study, fatigue crack growth rates (FCGR) of 7% nickel steel at room and cryogenic temperatures were evaluated using damage-coupled finite element analysis (FEA).
Seul-Kee Kim +6 more
doaj +1 more source