Results 31 to 40 of about 58,757 (315)
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
A Nonlinear Creep-damage Constitutive Model of Mudstone Based on the Fractional Calculus Theory [PDF]
Journal of Petroleum Science and Technology, 2017 During the flood development in an oil field, the creep characteristic of mudstone is one of the important factors causing casing damage. In this study, based on the theory of fractional order differential and taking into account the creep damage ...
Zhang Jun, Zeng Jia
doaj +1 more source
The Spatio-Temporal Evolution of Rock Failure Due to Blasting under High Stress
Applied Sciences, 2023 The research aims to investigate the failure characteristics of rock caused by blasting under high stress, explore the energy generation and its transfer and release in rock under the effects of blasting.
Gang Lei +3 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Damage Mechanics Experimental Background
Engineering Transactions, 1988 The present paper is a synthetic review of available experimental results, concerning damage nucleation and growth in various materials at diverse loading conditions. An emphasis is placed on the physical complexity of the damage processes. To this end,
M. Basista
doaj
Microscopic Multiple Fatigue Crack Simulation and Macroscopic Damage Evolution of Concrete Beam
Applied Sciences, 2019 Microcracks in concrete can coalesce into larger cracks that further propagate under repetitive load cycles. Complex process of crack formation and growth are essentially involved in the failure mechanism of concrete.
Baijian Wu +3 more
doaj +1 more source
Mechanical Chondrocyte Damage Thresholds
ASME 2012 Summer Bioengineering Conference, Parts A and B, 2012 Chondrocyte content in articular cartilage is very low. Only 2% to 5% of the tissue volume consists of chondrocytes [1]. Yet, these cells are responsible for maintenance of the tissue. Hence, the loss of chondrocytes that is often occurring at an early stage of cartilage degeneration is detrimental to articular cartilage.
Turnhout, van, M.C. +3 more
openaire +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source