Results 91 to 100 of about 2,598,216 (300)
Journal of Aeronautical Materials, 2016 Damage effects of electron irradiation with different energy on mechanical properties of polyethylene heat-shrinkable sleeves were studied by irradiating the sleeves with 45 keV, 1 MeV and 2 MeV electrons respectively.
LIU Yuming +4 more
doaj +1 more source
Proteostasis collapse is a driver of cell aging and death. [PDF]
, 2019 What molecular processes drive cell aging and death? Here, we model how proteostasis-i.e., the folding, chaperoning, and maintenance of protein function-collapses with age from slowed translation and cumulative oxidative damage.
de Graff, Adam MR +2 more
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The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Damage mechanism and protection measures for Yanchang shale Chang 7 reservoir, China
Frontiers in Earth ScienceThe Yanchang shale is a key resource in the Ordos Basin of Shaanxi, China. To optimize its extraction and production, it is crucial to understand formation damage mechanisms and implement effective solutions.
Penghao Lin
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Applied SciencesThe development of urban underground spaces has led to an increasing number of projects involving super-large-diameter shield tunnels, making research on their impact on existing structures particularly significant.
Zhiyuan Zhai, Kaihang Han
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Residual Stress in Wheels: Comparison of Neutron Diffraction and Ultrasonic Methods, with Trends in RCF [PDF]
, 2014 The critical damage mechanism on many GB passenger train wheels is Rolling Contact Fatigue (RCF) cracking in the rim. Evidence from field observations suggests that RCF damage occurs much more quickly as the wheelsets near the end of their life.
Bevan, Adam +3 more
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