Results 91 to 100 of about 5,485,239 (275)

DNA damage and repair mechanism. [DNA damage and repair mechanisms] [PDF]

, 1976
The ability of cells to survive in an environment specifically damaging to its DNA can be attributed to a variety of inherent repair mechanisms. This is a form of repair in which alterations are directly reversed to their original form. This reversibility is exemplified by the photoreactivation of ultraviolet-induced pyrimidine dimers.
openaire   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Research in the development of finite element software for creep damage analysis [PDF]

, 2013
This paper reports the development of finite element software for creep damage analysis. Creep damage deformation and failure of high temperature structure is a serious problem for power generation and it is even more technically demanding under the ...
Xu, Qiang, Liu, Dezheng, Lu, Zhongyu
core   +3 more sources

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Pore fracture structure evolution and damage failure mechanism of hot dry rock induced by temperature impact effect

Meitan xuebao
The geothermal resource originating from the hot dry rock is a form of clean and renewable energy, which has the advantages of stable, efficient, and permanent.
Yong SUN, Cheng ZHAI, Yuzhou CONG, Yangfeng ZHENG, Wei TANG, Shuai WANG, Yongshuai LAI, Yu WANG, Aikun CHEN   +8 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Acoustic Emission and Digital Image Correlation-Based Study for Early Damage Identification in Sandwich Structures

Applied Sciences
Understanding the deterioration and predominant damage mechanisms of structures is highly relevant, especially for safety-critical components. Non-Destructive Testing (NDT) plays a crucial role in assessing and monitoring their integrity by evaluating ...
Aitor García de la Yedra, Igor Erro, Javier Vivas, Oier Zubiri, Xabier Zurutuza, Ryan Sommerhuber, Matthias Kettner   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Mechanical Chondrocyte Damage Thresholds

ASME 2012 Summer Bioengineering Conference, Parts A and B, 2012
Chondrocyte content in articular cartilage is very low. Only 2% to 5% of the tissue volume consists of chondrocytes [1]. Yet, these cells are responsible for maintenance of the tissue. Hence, the loss of chondrocytes that is often occurring at an early stage of cartilage degeneration is detrimental to articular cartilage.
Turnhout, van, M.C., Vries, de, S.A.H., Donkelaar, van, C.C., Oomens, C.W.J.   +3 more
openaire   +3 more sources