Results 71 to 80 of about 4,459,810 (225)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Improvement of damage constitutive relationships for acid fracturing coals based on Weibull statistics

Meitan xuebao
Acid fracturing technology is one of the effective ways to improve the permeability of low permeability coal seam. The corrosion and splitting effect of acid solution is the key to softening and fracturing of coal.
Tianjun ZHANG, Xianfeng SONG, Mingkun PANG, Shan WU, Hongyu PAN, Hongjiao CHEN   +5 more
doaj   +1 more source

Mechanisms of Toxic Damage to Spermatogenesis [PDF]

Journal of the National Cancer Institute Monographs, 2005
Azoospermia and long-lasting testicular atrophy are common adverse consequences of cancer treatment. Chemotherapeutic agents may disrupt spermatogenesis by targeting various testicular cell types (Leydig cells, Sertoli cells, and germ cells) and by activating numerous molecular pathways involved in germ cell life-and-death decision making.
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Modeling damage of the hydrogen enhanced localized plasticity in stress corrosion cracking

, 2010
Stress corrosion cracking is an important and complex mode of failure in high-performance structural metals operating in deleterious environments, due to metallurgical, mechanical, and electrochemical factors.
Benbelaid, S., Belouchrani, M. A., Assoul, Y., Bezzazi, B.   +3 more
core   +2 more sources

Uniaxial Damage Mechanisms in Roller-Compacted Concrete Subjected to Freeze–Thaw Cycles

Buildings
Water-retaining roller-compacted concrete (RCC) dams suffer severe deterioration under coupled moisture ingress and freeze–thaw (F-T) cycles. To elucidate the damage mechanisms, this study employed industrial X-ray computed tomography (CT) synchronized ...
Kaide Liu, Xinping Wang, Yu Xia, Wenping Yue, Kekuo Yuan, Chaowei Sun, Dingbo Wang, Songxin Zhao   +7 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source