Results 71 to 80 of about 1,253,700 (267)

Freeze–Thaw Damage Model and Mechanism of Rubber Concrete with Recycled Brick–Concrete Aggregate

Buildings
This study investigated the effects of rubber substitution ratios (0%, 5%, 10%, 15%) on the frost resistance of rubber concrete with recycled brick–concrete aggregate (BRC).
Jiayu Zeng, Jiangfeng Dong, Siwei Du, Shucheng Yuan, Kunpeng Li, Xinyue Zhang, Xinyu Chen   +6 more
doaj   +1 more source

Experimental and Simulation Study of Low-Velocity Impact on Glass Fiber Composite Laminates with Reinforcing Shape Memory Alloys at Different Layer Positions

Applied Sciences, 2018
The effects of shape memory alloy (SMA) wires on the damage behavior of glass fibers/epoxy resin composite laminates for the case of low-velocity impact are investigated experimentally and numerically.
Min Sun, Mengzhou Chang, Zhenqing Wang, Hao Li, Xiaokun Sun   +4 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Pore fracture structure evolution and damage failure mechanism of hot dry rock induced by temperature impact effect

Meitan xuebao
The geothermal resource originating from the hot dry rock is a form of clean and renewable energy, which has the advantages of stable, efficient, and permanent.
Yong SUN, Cheng ZHAI, Yuzhou CONG, Yangfeng ZHENG, Wei TANG, Shuai WANG, Yongshuai LAI, Yu WANG, Aikun CHEN   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Acoustic Emission and Digital Image Correlation-Based Study for Early Damage Identification in Sandwich Structures

Applied Sciences
Understanding the deterioration and predominant damage mechanisms of structures is highly relevant, especially for safety-critical components. Non-Destructive Testing (NDT) plays a crucial role in assessing and monitoring their integrity by evaluating ...
Aitor García de la Yedra, Igor Erro, Javier Vivas, Oier Zubiri, Xabier Zurutuza, Ryan Sommerhuber, Matthias Kettner   +6 more
doaj   +1 more source

Mechanical Chondrocyte Damage Thresholds

ASME 2012 Summer Bioengineering Conference, Parts A and B, 2012
Chondrocyte content in articular cartilage is very low. Only 2% to 5% of the tissue volume consists of chondrocytes [1]. Yet, these cells are responsible for maintenance of the tissue. Hence, the loss of chondrocytes that is often occurring at an early stage of cartilage degeneration is detrimental to articular cartilage.
Turnhout, van, M.C., Vries, de, S.A.H., Donkelaar, van, C.C., Oomens, C.W.J.   +3 more
openaire   +3 more sources