Results 91 to 100 of about 5,478,320 (275)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Research in the development of finite element software for creep damage analysis [PDF]
, 2013 This paper reports the development of finite element software for creep damage analysis. Creep damage deformation and failure of high temperature structure is a serious problem for power generation and it is even more technically demanding under the ...
Xu, Qiang, Liu, Dezheng, Lu, Zhongyu
core +3 more sources
Meitan xuebaoThe geothermal resource originating from the hot dry rock is a form of clean and renewable energy, which has the advantages of stable, efficient, and permanent.
Yong SUN +8 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Applied SciencesUnderstanding the deterioration and predominant damage mechanisms of structures is highly relevant, especially for safety-critical components. Non-Destructive Testing (NDT) plays a crucial role in assessing and monitoring their integrity by evaluating ...
Aitor García de la Yedra +6 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Applied SciencesReinforced concrete shear wall structures (RCSWs) are commonly used as explosion-resistant chambers for storing hazardous chemical materials and housing high-pressure reaction equipment, serving to isolate blast waves and prevent chain reactions. In this
Hongkun Shang +4 more
doaj +1 more source
Siliao yanjiu, 2023 The intestine is an important organ for nutrient absorption and digestion of the body, and the intestinal mucosal barrier also plays an indispensable role.
LI Xu-nan +6 more
doaj