Results 141 to 150 of about 5,485,239 (275)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Macro-Meso Damage Mechanism of Sandstone Under Wet-Dry Cycles: A Study Based on Nuclear Magnetic Resonance Technology. [PDF]

Materials (Basel)
Wei Y, Niu F, Zhu S, Zhang J.
europepmc   +1 more source

Experimental study on damage mechanism of blood vessel by cavitation bubbles. [PDF]

Ultrason Sonochem, 2023
Liu Y, Luo J.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Progressive damage mechanism and multiscale characterization of hard sandstone-coal composite structures under loading. [PDF]

PLoS One
Dang J, Tu M, Zhang X, Bu Q.
europepmc   +1 more source

The rock damage mechanism of combined rock breaking with saw blade and conical pick. [PDF]

Sci Rep, 2023
Wang Z, Zeng Q, Wan L, Lu Z, Jiang H, Dewangan S.   +5 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Research on the damage mechanism and reservoir protection drilling fluid system of Jurassic reservoir in Zhenbei oilfield. [PDF]

Sci Rep
Wang J, He W, Zhang M, He C, Shi P.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Damage mechanism investigation on fiber reinforced recycled cement aggregate concrete in a cold region. [PDF]

Sci Rep
Li W, Li Z, Xu W, Ji Y.
europepmc   +1 more source