Results 81 to 90 of about 5,485,239 (275)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Damage characteristic of caisson gravity wharf subjected to underwater contact and near-field explosion

Baozha yu Chongji
To investigate the damage mechanism and load characteristics of caisson wharf under underwater contact and near-field explosion, a high-fidelity numerical model was conducted based on the scaled model tests of caisson wharf and verified by comparing the ...
Qi DONG, Jinghan LIU, Lingfeng LI, Yi GAO, Zhuobin WEI   +4 more
doaj   +1 more source

Mechanism of DNA damage tolerance

World Journal of Biological Chemistry, 2015
DNA damage may compromise genome integrity and lead to cell death. Cells have evolved a variety of processes to respond to DNA damage including damage repair and tolerance mechanisms, as well as damage checkpoints. The DNA damage tolerance (DDT) pathway promotes the bypass of single-stranded DNA lesions encountered by DNA polymerases during DNA ...
openaire   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Freeze–Thaw Damage Model and Mechanism of Rubber Concrete with Recycled Brick–Concrete Aggregate

Buildings
This study investigated the effects of rubber substitution ratios (0%, 5%, 10%, 15%) on the frost resistance of rubber concrete with recycled brick–concrete aggregate (BRC).
Jiayu Zeng, Jiangfeng Dong, Siwei Du, Shucheng Yuan, Kunpeng Li, Xinyue Zhang, Xinyu Chen   +6 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Mechanical Response and Interfacial Deterioration of Red Mud-Based Synthetic Sand Mortar Under Freeze–Thaw Cycles

Buildings
Freeze–thaw resistance is important for the use of red mud-based synthetic sand in cold regions. Mortars containing synthetic, standard, and fluvial sand were compared at a nominal water-to-cement ratio of 0.50 and cement-to-sand mass ratio of 1:3 ...
Kai Hu, Cuicui Ge
doaj   +1 more source

Experimental and Simulation Study of Low-Velocity Impact on Glass Fiber Composite Laminates with Reinforcing Shape Memory Alloys at Different Layer Positions

Applied Sciences, 2018
The effects of shape memory alloy (SMA) wires on the damage behavior of glass fibers/epoxy resin composite laminates for the case of low-velocity impact are investigated experimentally and numerically.
Min Sun, Mengzhou Chang, Zhenqing Wang, Hao Li, Xiaokun Sun   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source