Results 121 to 130 of about 3,676,094 (356)

Finite element modeling of sub-surface damage while machining aluminum based metal matrix composites [PDF]

, 2021
Usama Umer, Hisham Alkhalefah, Mustufa Haider Abidi, Muneer Khan Mohammed, Hossam A. Kishawy   +4 more
openalex   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Studying energy absorption in tapered thick walled tubes

Latin American Journal of Solids and Structures
In many engineering structures different energy absorption systems may be used to improve crashworthiness capability of the system and to control damages that may occur in a system during an accident.
P. Hosseini Tehrani, I. Ferestadeh
doaj   +1 more source

Preliminary Investigation into Modeling The Damage to Carbon Fibre Composites Due to the Thermo-electric Effects of a Lightning Strikes

, 2011
The impact of a lightning strike causes a short high electrical current burst through Carbon Fibre Composites (CFC). Due to the electrical properties of CFC the large current leads to a rapid heating of the surrounding impact area which degrades and ...
Chippendale, Richard, Golosnoy, Igor O., Lambert, J., Lewin, Paul, Murugan, G.S.   +4 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Study on physical and mechanical properties and freeze-thaw damage models of granite under freeze-thaw cycles

Frontiers in Built Environment
IntroductionTo describe the evolution of freeze-thaw damage in rocks and quantitatively analyze the degree of damage, a freeze-thaw damage model based on continuum damage mechanics and thermodynamics is proposed.MethodsTaking granite as the research ...
Song Xue, Yongqiong Hu, Yongqiong Hu, Chaojun Jia, Chaojun Jia, Liang Wang, Liang Wang   +6 more
doaj   +1 more source

Modified Non-Local Damage Model: Resolving Spurious Damage Evolution

Accurate prediction of damage and fracture evolution is critical for the safety design and preventive maintenance of engineering structures, however existing computational methods face significant limitations. On one hand, discrete damage and phase-field models are often computationally prohibitive for real world applications and they are less ...
Saji, Roshan Philip, Pantidis, Panos, Mobasher, Mostafa E.   +2 more
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Nephro- and hepatoprotective effect of Rosmarinus officinalis against damage induced with antiTB drugs using a chronic model [PDF]

, 2021
Siordia-Reyes Georgina A, Jorge Cornejo‐Garrido, María Adelina Jiménez-Arellanes   +2 more
openalex   +1 more source

Proteostasis collapse is a driver of cell aging and death. [PDF]

, 2019
What molecular processes drive cell aging and death? Here, we model how proteostasis-i.e., the folding, chaperoning, and maintenance of protein function-collapses with age from slowed translation and cumulative oxidative damage.
de Graff, Adam MR, Dill, Ken A, Santra, Mantu   +2 more
core