Results 81 to 90 of about 3,676,094 (356)
Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja +8 more
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Experimental characterization and numerical modeling of micromechanical damage under different stress states [PDF]
, 2013 The use of HSLA steels for the manufacture of automotive components is interesting from an engineering point of view. This family of steels, while possessing high strength, also has good formability and can be used in forming manufacturing processes.
ACHOURI, Mohamed +3 more
core +5 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Modeling of ductile damage using numerical analyses on the micro-scale [PDF]
, 2013 The presentation deals with a continuum damage model which has been generalized to take into account the effect of stress state on damage criteria as well as on evolution equations of damage strains.
Brünig, Michael +2 more
core
On a damage-plasticity approach to model concrete failure
, 2009 A damage-plasticity constitutive model for the description of fracture in plain concrete is presented. Two approaches, the local model comprising the adjustment of the softening modulus and the nonlocal model based on spatial averaging of history ...
Grassl, Peter
core +1 more source
Analyzing the sensitivity of a flood risk assessment model towards its input data [PDF]
, 2016 The Small Island Developing States are characterized by an unstable economy and low-lying, densely populated cities, resulting in a high vulnerability to natural hazards. Flooding affects more people than any other hazard.
De Maeyer, Philippe +4 more
core +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
A Model for Tracking Fronts of Stress-Induced Permeability Enhancement
, 2013 Using an analogy to the classical Stefan problem, we construct evolution equations for the fluid pore pressure on both sides of a propagating stress-induced damage front.
Karra, Satish +2 more
core +1 more source