Results 141 to 150 of about 1,571,262 (350)

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

Nature Communications
The Greatwall kinase inhibits PP2A-B55 phosphatase activity during mitosis to stabilise critical Cdk1-driven mitotic phosphorylation. Although Greatwall represents a potential oncogene and prospective therapeutic target, our understanding of the cellular
Róbert Zach, Michael Annis, Sandra M. Martin-Guerrero, Abdulrahman Alatawi, Kim Hou Chia, Megan Meredith, Kay Osborn, Nisha Peter, William Pearce, Jessica Booth, Mohan Rajasekaran, Samantha Dias, Lily Coleman-Evans, William R. Foster, Jon A. Harper, Alex D. Herbert, Catherine Tighe, Tristan Reuillon, Ryan West, Oliver Busby, Kamila Burdova, Damien Crepin, Sergi Ortoll, Kulthida Vaeteewoottacharn, Donniphat Dejsuphong, John Spencer, Hitesh Patel, Darren Le Grand, Thomas A. Hunt, David M. Andrews, Hiroyuki Yamano, Pedro R. Cutillas, Antony W. Oliver, Simon E. Ward, Helfrid Hochegger   +34 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The case of two self-enforcing international agreements for environmental protection [PDF]

Non-cooperative game theoretical models of self-enforcing international environmental agreements (IEAs) that employ the cartel stability concept of d'Aspremont et al.
Osmani, Dritan, Tol, Richard
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

STABILITY OF A DAMAGED LARGE-SPAN TRUSS IN THE SPATIAL STRUCTURE

, 2018
Мария Бергер, Mariya Berger
openalex   +2 more sources

STUDI PENINJAUAN PENGGUNAAN PERTAMAX SEBAGAI MODIFIER PADA ASBUTON BERAGREGAT CAMPURAN DINGIN UNTUK PERKERASAN JALAN [PDF]

, 2007
The road is a means of land transportation which consists of some materials, such as coarse aggregate, fine aggregate, filler (filler) and bitumen. In the process of maintenance, damage sometimes occur earlier than the service one of which is caused by ...
WIDYA, NOVA
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Aircraft carrier stability in damaged condition

, 2010
Building today’s aircraft carriers is the culmination of science and the art of shipbuilding for maritime nations with this type of vessel in its naval fleet. The wartime role of aircraft carriers during the 20th century evolved rapidly, so in less than 50 years the aircraft carrier has changed from an auxiliary warship of limited combat value, into ...
Slapničar, Vedran, Ukas, Božidar
openaire   +3 more sources

ACTIVE LEARNING FOR ENHANCED UNDERSTANDING OF “SHIP DAMAGE STABILITY”

, 2018
Kåre Johansen, Bjorn Morten Batalden
openalex   +2 more sources

BRCA2 Regulates Homologous Recombination in Response to DNA Damage: Implications for Genome Stability and Carcinogenesis [PDF]

, 2005
Christine Abaji, Isabelle Cousineau, Abdellah Belmaaza   +2 more
openalex   +1 more source