Results 131 to 140 of about 619,613 (312)
Molecular Oncology, 2011 There is increasing evidence that glioblastoma possess ‘stem‐like’ cells, low concentrations of which can initiate a tumour. It has been proposed that these cells are radioresistant, and that this property contributes to the poor treatment outcomes of ...
Mariella Mannino, Anthony J. Chalmers
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Flood damage, vulnerability and risk perception - challenges for flood damage research [PDF]
The current state-of-the-art in flood damage analysis mainly focuses on the economic evaluation of tangible flood effects. It is contended in this discussion paper that important economic, social and ecological aspects of flood-related vulnerabilities ...
Meyer, Volker, Messner, Frank
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Effect of loading on the damage assessment of reinforced concrete beams [PDF]
, 2009 Quantitative condition assessment of structures has been traditional using proof load test leading to an indication of the load-carrying capacity. Alternative approaches using ultrasonic, dynamics, etc.
Hao, Hong +2 more
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Life-cycle risk (damage stability) management of passenger ships [PDF]
, 2015 Inadequate damage stability, the Achilles heel of passenger ships, has been a critical research objective that industry and academia delved to improve every time following accidents with passenger ships.
Vassalos, Dracos, Bi, Yu
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Revisiting the mechanisms of clay damage [PDF]
, 2016 Molecular dynamics simulations were used to investigate the underlying mechanisms of water interaction with Wyoming-type montmorillonites. The study focused on (1) the clay swelling process for different cations with the same charge (Na+ and K+), and (2)
Perez, Felipe
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