Results 111 to 120 of about 1,571,262 (350)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair
Nature Communications, 2018 The mechanism through which Drosha and Dicer affect DNA repair is not clear. Here the authors use a high-throughput approach to uncover the role of Drosha in promoting DNA:RNA hybrids at DNA damaged sites.
Wei-Ting Lu +9 more
doaj +1 more source
Repair of DNA Double-Strand Breaks in Heterochromatin
Biomolecules, 2016 DNA double-strand breaks (DSBs) are among the most damaging lesions in DNA, since, if not identified and repaired, they can lead to insertions, deletions or chromosomal rearrangements.
Felicity Z. Watts
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex
Nature Communications, 2018 The R2TP/PFDL co-chaperone facilitates assembly of RNA polymerase II and PI3-kinase-like kinases such as mTOR by a so far unknown mechanism. Here authors provide the cryo-EM structure of human R2TP, which shows how RPAP3 serves as a flexible platform to ...
Fabrizio Martino +11 more
doaj +1 more source
The Involvement of Aβ42 and Tau in Nucleolar and Protein Synthesis Machinery Dysfunction
Frontiers in Cellular Neuroscience, 2018 Alzheimer’s disease (AD) is the most common form of dementia and is distinguished from other dementias by observation of extracellular Amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles, comprised of fibrils of Aβ and tau protein ...
Mahmoud B. Maina +4 more
doaj +1 more source
Designing for damage stability beyond design level [PDF]
, 2016 This paper describes the background and provides the rationale and the framework to embrace all feasible measures (passive/design and active/operational – normal and emergencies) for improving the damage survivability of RoRo Passenger ships.
Boulougouris, Evangelos +3 more
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The application of encapsulation material stability data to photovoltaic module life assessment [PDF]
For any piece of hardware that degrades when subject to environmental and application stresses, the route or sequence that describes the degradation process may be summarized in terms of six key words: LOADS, RESPONSE, CHANGE, DAMAGE, FAILURE, and ...
Coulbert, C. D.
core +1 more source