Results 91 to 100 of about 619,613 (312)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Break-induced replication is enhanced by a phospho-activated RPA-binding module in Pol32
Nature CommunicationsBreak-induced replication (BIR) facilitates single-ended DNA double-strand break (DSB) repair. Upon homologous recombination-mediated strand invasion into a homologous repair template, BIR is catalysed by a minimal replisome comprising PCNA, DNA ...
David Jones +4 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Finite element analysis of fatigue damage of composite laminated structures [PDF]
, 2002 Composite materials are increasingly believed to be the materials of the future with potential for application in high perfon-nance structures. One of the reasons for that is the indication that composite materials have a rather good rating with regard
Hegaze, Moutaz Mohamed Ebrahim
core
eLife, 2018 TOPBP1 and its fission yeast homologue Rad4, are critical players in a range of DNA replication, repair and damage signalling processes. They are composed of multiple BRCT domains, some of which bind phosphorylated motifs in other proteins. They thus act
Matthew Day +5 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Analisis Probabilistik Damage Stability Tongkang Tipe Ballastable [PDF]
, 2018 Setiap kapal yang beroperasi di laut memiliki resiko kecelakaan yang bisa mengakibatkan kebocoran pada bagian lambung kapal. Perhitungan stabilitas untuk kondisi tersebut diharuskan menggunakan perhitungan damage stability karena perhitungan intact ...
Hidayatulloh, Annas
core
A Monte Carlo Based Simulation Method for Damage Stability Problems [PDF]
, 2019 To cope with future developments of the SOLAS 2009 B1, damage stability investigations must become a central part of the initial design phase. If damage stability calculations are performed in the classical way, they are very time consuming with respect ...
Stefan Krüger +3 more
core +1 more source
Cdk1 Restrains NHEJ through Phosphorylation of XRCC4-like Factor Xlf1
Cell Reports, 2014 Eukaryotic cells use two principal mechanisms for repairing DNA double-strand breaks (DSBs): homologous recombination (HR) and nonhomologous end-joining (NHEJ). DSB repair pathway choice is strongly regulated during the cell cycle.
Pierre Hentges +4 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source