Results 81 to 90 of about 1,571,262 (350)
Cdk1 Restrains NHEJ through Phosphorylation of XRCC4-like Factor Xlf1
Cell Reports, 2014 Eukaryotic cells use two principal mechanisms for repairing DNA double-strand breaks (DSBs): homologous recombination (HR) and nonhomologous end-joining (NHEJ). DSB repair pathway choice is strongly regulated during the cell cycle.
Pierre Hentges +4 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Principles of meiotic chromosome assembly revealed in S. cerevisiae
Nature Communications, 2019 During meiotic prophase chromosomes organise into a series of chromatin loops, but the mechanisms of assembly remain unclear. Here the authors use Saccharomyces cerevisiae to elucidate how this elaborate three-dimensional chromosome organisation is ...
Stephanie A. Schalbetter +4 more
doaj +1 more source
Experimental study of thin part vibration modes in machining [PDF]
, 2008 The machining of thin walls generally generates milling chatter, that damage surface roughness and manufacturing tools. Stability lobes which include natural frequencies are successful in case of tool chatter.
Arnaud, Lionel +2 more
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Molecular basis for PrimPol recruitment to replication forks by RPA
Nature Communications, 2017 PrimPol is a multifunctional replicative enzyme that can bypass DNA damage, as well as reprime replication restart. Here, the authors have elucidated how PrimPol is recruited to stalled replication forks via specific interactions with RPA, which ...
Thomas A. Guilliam +9 more
doaj +1 more source
X-ray Computed Tomography (CT) to Scan the Structure and Characterize the Mud Cake Incorporated with Various Magnetic NPs Concentration: An Application to Evaluate the Wellbore Stability and Formation Damage [PDF]
, 2023 Rasan Sarbast Faisal +3 more
openalex +1 more source
Machining stability and machine tool dynamics [PDF]
, 2007 Machining is a common manufacturing process in industry due to its high flexibility and ability to produce parts which excellent quality. The productivity and quality in machining operations can be limited by several process constraints one of which is ...
Budak, Erhan
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
DNA Ligase C and Prim-PolC participate in base excision repair in mycobacteria
Nature Communications, 2017 Ligase D is a conserved DNA repair protein complex that repairs double-strand breaks in stationary phase prokaryotes. Here the authors show that orthologous Ligase C has a role in base excision repair during stationary phase.
Przemysław Płociński +7 more
doaj +1 more source