Results 51 to 60 of about 874,446 (309)
Applied Sciences, 2020 The 22 wt.% Cr, fully ferritic stainless steel Crofer®22 H has higher thermomechanical fatigue (TMF)- lifetime compared to advanced ferritic-martensitic P91, which is assumed to be caused by different damage tolerance, leading to differences in crack ...
Bastian Blinn +4 more
doaj +1 more source
RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair [PDF]
, 2020 Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) stands out for its versatility,
Cortés Ledesma, Felipe +4 more
core +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Radiation damage tolerant nanomaterials
Materials Today, 2013 Designing a material from the atomic level to achieve a tailored response in extreme conditions is a grand challenge in materials research. Nanostructured metals and composites provide a path to this goal because they contain interfaces that attract, absorb and annihilate point and line defects.
Beyerlein, Irene J. +5 more
openaire +3 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Energy-absorbing wood composite for improved damage tolerance inspired by mollusc shells
Materials Research Express, 2020 The crossed lamellar structure (CLS) found in mollusc shells is an excellent example for nature’s ability to form complex hierarchical microstructures with a remarkable balance between strength and toughness.
Maximilian Pramreiter +6 more
doaj +1 more source
Development of methologies to study the damage tolerance of aeronautical and aerospace composite structures [PDF]
, 2008 Mechanics of Advanced Materials research group (Department of Continuum Mechanics and Structural Analysis) of the University Carlos III of Madrid (Spain) offers their experience in the analysis and modelization of high and low velocity impact behaviour ...
Barbero Pozuelo, Enrique +1 more
core +1 more source
Tissue damage control in disease tolerance [PDF]
Trends in Immunology, 2014 Immune-driven resistance mechanisms are the prevailing host defense strategy against infection. By contrast, disease tolerance mechanisms limit disease severity by preventing tissue damage or ameliorating tissue function without interfering with pathogen load.
Miguel P. Soares +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source