Results 81 to 90 of about 874,446 (309)
Comparison of Riveted Panel and Integral Panel for Damage Tolerance by using FEA [PDF]
, 2014 Damage tolerance capability refers to the load carrying capacity of a damaged structure. In an aircraft metallic structure damage is the fatigue crack. The presence of a fatigue crack reduce the load carrying capacity of a structure.
Shantharaja, M., Srinivas, K.R.
core
Mitochondrial DNA repair and damage tolerance
Frontiers in Bioscience, 2017 The accurate maintenance of mitochondrial DNA (mtDNA) is required in order for eukaryotic cells to assemble a functional electron transport chain. This independently-maintained genome relies on nuclear-encoded proteins that are imported into the mitochondria to carry out replication and repair processes.
Alexis, Stein, Elaine A, Sia
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Durability and damage tolerance of Large Composite Primary Aircraft Structure (LCPAS) [PDF]
Analysis and testing addressing the key technology areas of durability and damage tolerance were completed for wing surface panels. The wing of a fuel-efficient, 200-passenger commercial transport airplane for 1990 delivery was sized using graphite-epoxy
Mccarty, John E., Roeseler, William G.
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The Stab Resistance of Bombyx Mori Silk Cocoons
Macromolecular Materials and EngineeringThis study considers the mechanical response of Bombyx mori silk cocoons to knife stabbing, a simple but controlled way of simulating predaceous penetration.
Ateeq Ur Rehman +2 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Engineering ReportsAdditive Manufacturing (AM) has revolutionized the production industry by offering design freedom with shorter lead times and reduced material wastage. However, the damage tolerance (DT) of AM parts is a significant concern due to their microstructural ...
Zia Uddin +4 more
doaj +1 more source
Modelling of impact damage and permanent indentation on laminate composite plate [PDF]
, 2010 This paper deals with impact damage and permanent indentation modelling. A model enabling the formation of damages developing during a low velocity / low energy impact test on laminate composite panels has been elaborated.
Barrau, Jean-Jacques +2 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source