Results 81 to 90 of about 875,259 (309)
Mitochondrial DNA repair and damage tolerance
Frontiers in Bioscience, 2017 The accurate maintenance of mitochondrial DNA (mtDNA) is required in order for eukaryotic cells to assemble a functional electron transport chain. This independently-maintained genome relies on nuclear-encoded proteins that are imported into the mitochondria to carry out replication and repair processes.
Alexis, Stein, Elaine A, Sia
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Durability and damage tolerance of Large Composite Primary Aircraft Structure (LCPAS) [PDF]
Analysis and testing addressing the key technology areas of durability and damage tolerance were completed for wing surface panels. The wing of a fuel-efficient, 200-passenger commercial transport airplane for 1990 delivery was sized using graphite-epoxy
Mccarty, John E., Roeseler, William G.
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Overexpression of beta-carotene hydroxylase enhances stress tolerance in Arabidopsis [PDF]
, 2002 Plant stress caused by extreme environmental conditions is already a principal reason for yield reduction in crops. The threat of global environment change makes it increasingly important to generate crop plants that will withstand such conditions ...
Davison, P.A., Horton, P., Hunter, C.N.
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The Stab Resistance of Bombyx Mori Silk Cocoons
Macromolecular Materials and EngineeringThis study considers the mechanical response of Bombyx mori silk cocoons to knife stabbing, a simple but controlled way of simulating predaceous penetration.
Ateeq Ur Rehman +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Engineering ReportsAdditive Manufacturing (AM) has revolutionized the production industry by offering design freedom with shorter lead times and reduced material wastage. However, the damage tolerance (DT) of AM parts is a significant concern due to their microstructural ...
Zia Uddin +4 more
doaj +1 more source
A damage tolerance comparison of IM7/8551 and IM8G/8553 carbon/epoxy composites [PDF]
A damage tolerance study of two new toughened carbon fiber/epoxy resin systems was undertaken as a continuation of ongoing work into screening new opposites for resistance to foreign object impact.
Lance, D. G., Nettles, A. T.
core +1 more source