Results 121 to 130 of about 670,121 (313)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Damage analysis of pressure pipes under high temperature and variable pressure conditions [PDF]

, 2006
The problem of non-linear stress analysis of creeping reinforced pipes under constant pressure has been treated in a recent work [1]. In the present work, a damage accumulation analysis of the above problem is attempted taking into account the non ...
Vlachakis, N. V., Kyriakos, K., Kartsonaki, E., Pavlou, D., Kouskouti, M., Arsenos, P., Zafiris, K., Papassalouros, D.   +7 more
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Axial compression damage constitutive model and damage characteristics of fly ash/silica fume modified magnesium phosphate cement after being treated at different temperatures

Reviews on Advanced Materials Science
The relationship between fly ash (FA) and silica fume (SF)-modified magnesium phosphate cement (MPC) at varying temperatures remains unclear. In this study, the mechanical properties and damage characteristics of FA- and SF-modified MPC at 20–1,000°C ...
Guo Boyu, Zhu Jincai, Meng Xiaokai, Cao Qi   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Intrasubject variability in Potential Early Markers of Sensorineural Hearing Damage

The Journal of the Acoustical Society of America
ABSTRACT The quest for noninvasive early markers for sensorineural hearing loss (SNHL) has yielded diverse measures of interest. However, comprehensive studies evaluating the test-retest reliability of multiple measures and stimuli within a single study are scarce, and a standardized clinical protocol for robust early markers of SNHL ...
Nele De Poortere, Sarineh Keshishzadeh, Hannah Keppler, Ingeborg Dhooge, Sarah Verhulst   +4 more
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Ultrasonic testing and evaluation method for hydraulic fracturing coal by voltage pulse

Youqicang pingjia yu kaifa, 2020
In order to quantitatively evaluate the fracturing effect of hydraulic fracturing by voltage pulse on coal rocks, and determine that whether the technology is suitable for the voltage and water pressure loading in engineering practice or not, the voltage
BAO Xiankai, CAO Jiaxing, ZHAO Gang, GUO Junyu, LIU Yuan, ZHAO Jinchang, WU Jinwen   +6 more
doaj  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Multivariate statistical analysis for damage and delamination in composite structures

, 2013
The article is devoted to the analysis of the vibration response of composite laminates .Our aim is to develop a method for analysis of the vibration response of structures made of composites which will also be used to develop a vibration-based health ...
Trendafilova, Irina, Garcia, David
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