Results 191 to 200 of about 6,560,570 (376)

Increased amounts and stability of telomeric repeat-containing RNA (TERRA) following DNA damage induced by etoposide [PDF]

, 2019
Bong-Kyeong Oh, Yoojung Choi, Jaeman Bae, Won Moo Lee, Jeong‐Kyu Hoh, Joong Sub Choi   +5 more
openalex   +1 more source

Phosphatidylethanolamine Alleviates Osteoarthritis Progression by Inhibiting Oxidative Stress-Induced Chondrocyte Ferroptosis in a Lysosomal-Dependent Manner. [PDF]

Int J Gen Med
Zheng H, Zhu Z, Zhu J, Chen D, Ruan R, Ning R.   +5 more
europepmc   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

Role of autophagy in tumorigenesis and drug resistance: molecular mechanisms and therapeutic targets. [PDF]

Mol Biomed
Zhu J, Lv L, Yan Y, Wang S, Lu X, Ma X, Sun X, Qin Y, Wu H, Yu G, Wang Q, Liang X.   +11 more
europepmc   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Centrifugal loading finite element method for slope stability under damage-seepage coupling effect

, 2019
XU Meng-fei 1, JIANG An-nan 1, DUAN Long-mei 2, JIAO Ming-wei 2, HU Xue-feng 2
openalex   +2 more sources

Strategies for Enhancing the Stability of High-Electric-Field Perovskite Single-Crystal Radiation Detectors. [PDF]

ACS Energy Lett
Zhang W, Wang H, Fu J, Wang P, Dong H, Gao Z, Shao Y.   +6 more
europepmc   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

Mitochondrial homeostasis: the central hub governing the progression of atherosclerosis. [PDF]

Precis Clin Med
Liu H, Zhao S, Gao H, Wang Y, Gao J, Guo P, Yang Y, Cui W, Zhang S, Shi Y, Xie G, Han Y, Zhou J, Zhang Q, Zou Y.   +14 more
europepmc   +1 more source