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Role of senataxin in DNA damage and telomeric stability
DNA Repair, 2011Ataxia with oculomotor apraxia type 2 (AOA2) is an autosomal recessive neurodegenerative disorder characterized by cerebellar ataxia and oculomotor apraxia. The gene mutated in AOA2, SETX, encodes senataxin (SETX), a putative DNA/RNA helicase. The presence of the helicase domain led us to investigate whether SETX might play a role in DNA damage repair ...
DE AMICIS, ANDREA +5 more
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Stability Problems for Plates with Short-Term Damageability
International Applied Mechanics, 2001The authors consider the problem on plates stability with account for microfractures in the material modelled by stochastically located empty pora. Two approaches are proposed for stability investigation of the plate with microfractures which are based on the well-known models of stability theory of elastoplastic bodies incorporating the concepts of ...
Khoroshun, L. P., Babich, D. V.
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2019
Although aviation, nuclear, processing, etc. industries have long ago adopted and established preventative frameworks and procedures to safeguard against unwanted outcomes of daily operations, the maritime industry still places the emphasis on the mitigation of consequences following an accident.
George Mermiris, Dracos Vassalos
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Although aviation, nuclear, processing, etc. industries have long ago adopted and established preventative frameworks and procedures to safeguard against unwanted outcomes of daily operations, the maritime industry still places the emphasis on the mitigation of consequences following an accident.
George Mermiris, Dracos Vassalos
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ATM signaling and genomic stability in response to DNA damage
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005DNA double strand breaks represent the most threatening lesion to the integrity of the genome in cells exposed to ionizing radiation and radiomimetic chemicals. Those breaks are recognized, signaled to cell cycle checkpoints and repaired by protein complexes. The product of the gene (ATM) mutated in the human genetic disorder ataxia-telangiectasia (A-T)
Lavin, Martin F. +5 more
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Stability degradation and redundancy in damaged structures
Engineering Structures, 2005Abstract The objective of this paper is to assess the promise of a novel tool for structural safety decision-making in severe unforeseen hazards. A straightforward measure is put forward for measuring the intensity of unforeseen hazards: the number of connected members “removed” from a structure in a brittle fashion.
B.W. Schafer, P. Bajpai
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Issues Related to Damage Stability
2019This chapter attempts to provide a brief historical overview of how the demands for increased safety, in combination with advances in computing hardware and software, have resulted in changes to the regulatory framework governing damage stability.
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Stability, instability, and localization in materials with damage
Journal of Rheology, 1984Generally, continuum theories of materials with damage treat the damage as an internal state variable, a variable whose evolution is governed by a rate‐type law. There is quite ample precedent, however, to treat such a quantity as governed instead by an equation of balance in addition to the conventional ones for mass, momentum, energy, and entropy ...
S. L. Passman, T. G. Trucano
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Thermal stability and radiation damage in the phthalocyanines
Australian Journal of Chemistry, 1974The phthalocyanine (pc) complexes of a number of metals have been prepared. The e.p.r. spectra of the paramagnetic pc complexes (VO2+, Cr2+, Mn2+, Co2+, Cu2+, Mo2+) show metal ion resonances, while those of the diamagnetic pc complexes (H22+, Na22+, Mg2+, Ni2+, Zn2+, Pd2+, Cd2+, Sn2+, Pt2+ and Pb2+) generally give free spin resonances with g ≈ 2.003 ...
JF Boas, PE Fielding, AG MacKay
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Beach scraping — Is it damaging to beach stability?
Coastal Engineering, 1983Abstract Beach scraping is removal of material from the lower part of the beach for deposition on the higher part of the beach or at the dune toe. Beach scraping has become a controversial subject, as it is sometimes claimed that it does little good to the beach in question, and is harmful to adjacent beaches.
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