Results 141 to 150 of about 361,673 (283)
Advanced Science, EarlyView.MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han +24 more
wiley +1 more source
Multiphoton Quantum Reservoirs For Robust Multidimensional Computing
Advanced Science, EarlyView.Projective measurements reveal hidden multidimensional quantum networks within classical multiphoton fields, enabling robust quantum reservoirs for room‐temperature quantum simulation, prediction, and information processing. These networks transform noisy classical photonic platforms into scalable quantum computational architectures.
Mingyuan Hong +10 more
wiley +1 more source
Based on a fluid-structure interaction analysis (FSIA), the theoretical solution is developed for an integrated spherical shell-damping layer-water interaction system subjected to an internal sinusoidal pressure excitation. The effect of damping layer on
Xing, J.T., Tan, M., Jiang, W.K.
core +1 more source
Advanced Science, EarlyView.This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu +10 more
wiley +1 more source
An investigation into the design for vibration damping of extended length tool holders [PDF]
This thesis presents a theoretical and experimental investigation into the design of extended length tool holders, with specific emphasis on vibration damping and the attenuation of chatter in boring bars.
Shirvani, Ayoub
core
Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen +10 more
wiley +1 more source
Advanced Science, EarlyView.Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang +4 more
wiley +1 more source
Advanced Science, EarlyView.AM symbiosis induces GhWAK13 to promote fungal colonization. GhNTF3 negatively regulates symbiosis by promoting SA biosynthesis. GhWAK13 sequesters GhNTF3 at the membrane, limiting its nuclear translocation and relieving SA‐mediated suppression. Under Verticillium stress, GhNTF3 enters the nucleus and interacts with GhJAZ6 to activate SA signaling ...
Shuangjie Jia +10 more
wiley +1 more source
Magnetic Water Cleaning of Estrogens via Tight yet Dynamic Binding to Nanoparticles
Advanced Science, EarlyView.Micropollution is one of the big challenges humanity faces with estrogen hormones being emerging pollutants of concern. Here, a supramolecular design strategy is presented that generates a simple nano‐adsorbent material to magnetically remove low‐concentrated estrogens from water.
Lukas Müller +25 more
wiley +1 more source
Advanced Science, EarlyView.Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian +10 more
wiley +1 more source