Results 221 to 230 of about 1,824,759 (302)

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

open access: yesAdvanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger   +8 more
wiley   +1 more source

Highly Repeatable Fibrous Crack‐Based Strain Sensor for Multichannel Continuous Tremor Monitoring in Parkinson's Disease and Essential Tremor

open access: yesAdvanced Science, EarlyView.
This study proposes a patch‐type tremor monitoring system based on high‐repeatable fibrous crack‐based strain sensor, capable of simultaneously measuring tremor in multiple locations such as thumb, index, and wrist. Through clinical trials involving Parkinson's disease and essential tremor patients, the proposed system demonstrates its potential as a ...
Chiwon Song   +12 more
wiley   +1 more source

Energy Dissipation in WSe<sub>2</sub> Opto-Acoustic Resonators. [PDF]

open access: yesJ Phys Chem Lett
Trepalin V   +8 more
europepmc   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

open access: yesAdvanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan   +14 more
wiley   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang   +5 more
wiley   +1 more source

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

open access: yesAdvanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang   +12 more
wiley   +1 more source

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