Results 41 to 50 of about 359,568 (270)

Tim1 Deficiency Mediates Gestational Hyperglycemia‐Related Syncytiotrophoblast Dysfunction and Fetal Growth Restriction

open access: yesAdvanced Science, EarlyView.
Hyperglycemia during pregnancy impairs the fusion of trophoblast cells into syncytiotrophoblasts, leading to fetal growth restriction. This impaired fusion is mediated by Tim1 downregulation via hyperglycemia‐induced ROS. Antioxidant therapy during pregnancy promotes syncytiotrophoblast formation by upregulating Tim1 expression, thus alleviating fetal ...
Junsen She   +14 more
wiley   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

open access: yesAdvanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen   +8 more
wiley   +1 more source

Quelques considérations sur l'Art Rupestre Schématique d'Andalousie

open access: yesZephyrus, 2009
Parmi les grandes étapes artistiques parcourues par l'humanité au cours de la préhistoire, l'art rupestre schématique de la péninsule ibérique occupe une place de premier plan, non seulement par sa grande extensión géographique, mais aussi par les ...
Lya DAMS, Marcel DAMS
doaj  

A Hybrid Particle/Finite Element Model with Surface Roughness for Stone Masonry Analysis

open access: yesApplied Mechanics, 2022
Circular and spherical particle models are a class of discrete elements (DEM) that have been increasingly applied to fracture studies of quasi-brittle materials, such as rock and concrete, due to their proven ability to simulate fracture processes ...
Nuno Monteiro Azevedo, José V. Lemos
doaj   +1 more source

Effects of maternal subnutrition during early pregnancy on cow hematological profiles and offspring physiology and vitality in two beef breeds [PDF]

open access: yes, 2019
This experiment evaluated the effects of subnutrition during early gestation on hematology in cows (Bos Taurus) and on hematological, metabolic, endocrine, and vitality parameters in their calves.
Almaguer C.   +9 more
core   +2 more sources

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

open access: yesAdvanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su   +4 more
wiley   +1 more source

Dams [PDF]

open access: yes
The construction of large dams is one of the most costly and controversial forms of public infrastructure investment in developing countries, but little is known about their impact.
Esther Duflo, Rohini Pande
core   +3 more sources

A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects

open access: yesAdvanced Science, EarlyView.
Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi   +12 more
wiley   +1 more source

Disaggregation Model of Tigris River Inflow into a Proposed Makhol Reservoir Using Parametric Approach

open access: yesTikrit Journal of Engineering Sciences
Since Makhol dam is planned to be constructed on Tigris River to the north of Baiji discharge measurement station, it is essential to study the nature of inflow into this reservoir.
Aaisha Mohand Yahya   +2 more
doaj   +1 more source

Il “Saul” di Vittorio Alfieri

open access: yesAltre Modernità, 2011
My paper analyzes Vittorio Alifieri’s tragedy Saul. The author writes the tragedy after reading the Bible, and particularly Samuel’s first book. Alfieri is enthusiastic about the biblical text, thanks to its “sublime” theme and style, very useful for ...
Paola Trivero
doaj   +1 more source

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