Results 1 to 10 of about 2,637,668 (148)
Inflammation induced by snake venoms optimizes envenomation. [PDF]
J PhysiolAbstract figure legend Schematic illustrating mechanisms underlying direct vascular absorption and subsequent movement of venom toxins into the tissues consequent to snakebite. A, snakebite into prey deposits venom toxins into the tissue interstitium, with the venom then causing acute inflammation primarily in venules.van Helden DF, Spratt N, Dosen PJ, McFadden SA, Holdsworth J, Beard DJ, Coupland K, Jobling P, Hardy TA, Laver DR. +9 moreeuropepmc +2 more sourcesSalmonella Typhi asparaginase-dependent activation of GCN2 promotes bacterial killing in murine macrophages [PDF]
Infection and ImmunityMany intracellular pathogens stimulate host cell stress by directly or indirectly causing an imbalance in host nutrients. Depletion of amino acid pools, in particular, can act as a danger signal to infected cells.Zachary M. Powers, Michael J. McFadden, Gi Young Lee, Tracey Schultz, Luiza A. Castro Jorge, Daniel F. Edwards, Simon Sanchez-Paiva, Jonathan Z. Sexton, Katherine R. Spindler, Jeongmin Song, Mary X. O'Riordan +10 moredoaj +2 more sourcesResponsive stimulation of the thalamus for idiopathic generalized epilepsy: Results of the randomized controlled NAUTILUS trial through 18 months. [PDF]
EpilepsiaAbstract Objective
This study was undertaken to evaluate the safety and effectiveness of responsive thalamic stimulation as adjunctive therapy for drug‐resistant idiopathic generalized epilepsy (IGE) with generalized tonic–clonic seizures (GTCSs). Methods
NAUTILUS is a prospective, multicenter, single‐blind, randomized sham‐controlled pivotal trial ...Uysal U, Landazuri P, Burdette DE, Patra S, Crudele AN, Englot DJ, Gavvala JR, Tandon N, Pati S, Kaye LC, Ojemann S, Barnett D, Neimat J, Palade AE, Rahimpour S, Arain AA, Richardson RM, Cash SS, Salanova V, Urban A, Welch WP, Gonzalez-Martinez JA, Van Gompel JJ, Starnes K, Spencer D, Ernst LD, Amin U, Rivera-Cruz A, Dugan P, Fajardo M, Lallas M, Jobst BC, Odom N, Roland JL, Willie JT, Sheth SA, Goldman AM, Skidmore CT, Wu C, Drees C, Parker J, Ganguly TM, Szaflarski J, Ghatan S, Johnson L, Norman J, Wingeier B, Seale CG, Morrell MJ, Nautilus Study Group. +49 moreeuropepmc +2 more sourcesOral administration of rumen-protected choline to ewes during the periconceptional period skews the sex ratio of lambs [PDF]
Reproduction and FertilityFeeding rumen-protected choline (RPC) to beef cows during the periconceptional period has been reported to alter embryonic development to reduce weaning weight of the resultant calves. Here, it was tested whether oral administration of RPC to ewes during Masroor Sagheer, Quinn A Hoorn, Daniel Carballo, Mariangela B C Maldonado, Jade A Paxton, Brittany N Diehl, Azmeera Thirupathi, Thainá Minela, Joseph W McFadden, Ky G Pohler, Peter J Hansen +10 moredoaj +2 more sourcesRandomised controlled trial comparing antibiotic cement bead pouch versus negative pressure wound therapy for the management of severe open tibia fracture wounds: Beads versus VAC (BvV) protocol [PDF]
BMJ OpenIntroduction Early open fracture management aims to minimise the risk of complications. For the most severe open fracture wounds, multiple irrigation and debridement surgeries are required to overcome severe wound contamination, to reassess the evolving ... , David Sanders, Mark Lee, Lehana Thabane, James Harris, Daniel Fitzpatrick, John Read, Nathan N O’Hara, Robert V O’Toole, Anthony D Harris, Mohit Bhandari, Ernesto Guerra-Farfán, Rebecca Smith, Clifford Jones, Shivam Patel, Anthony Brown, Gregory M Schrank, Paula McKay, Sheila Sprague, Jonathan Arnold, Yasmin Degani, Debra Marvel, Nicholas Smith, Michael McKee, Maria Jimenez, Aswinkumar Vasireddy, Diane Lourenco, Raymond Pensy, Gerard Slobogean, Eric Zhu, Nigar Sultana, Brian Sauer, Thomas Jones, Todd McKinley, Greg Gaski, Joshua L Gary, MaryBeth Horodyski, Paul Whiting, Robert Hymes, Steven Papp, Andrew Furey, Trevor Stone, Kelly Apostle, Dory Boyer, Farhad Moola, Bertrand Perey, Darius Viskontas, Brian Mullis, Tyson Schrickel, Barbara Hileman, Elisha Chance, Sarah MacRae, Jennifer Robinson, Jeffrey Potter, Brandon Fisher, Marissa Bonyun, Lauren Hill, Emil Schemitsch, Joseph Walker, Mark Vrahas, Emily Williams, Ines Reichert, Dale Williams, Marissa Pazik, Brad Petrisor, Sofia Bzovsky, Thomas Higgins, Graham J Dekeyser, Darin M Friess, Zachary M Working, Megan Walsh, Yongdong Ouyang, Lucas S Marchand, Gene Kim, Sapan Shah, Sheena Mendoza, Grace Phillips, Philip Lim, Michael Sridhar, Jonathan Riley, Matthew Denkers, Jeffrey L Wells, Jayden Lee, David W Grainger, Gregory J Della Rocca, Patrick J Kellam, Robert D Zura, I Leah Gitajn, Kyle J Jeray, Roman M Natoli, Patrick F Bergin, Jennifer E Hagen, Ashley E Levack, Joan N Hebden, Franca Mossuto, Cassandra Tsoutsounakis, David Pogorzelski, Hailey Pineda, Conor Kleweno, Emily Wagstrom, Brittney A Kay, Chuan Silvia Li, Kiara Pannozzo, Lara L. Virgilio, Tessa Johnston, Mark Gage, Andrea Howe, Heather Phipps, Shawnell Stokes, LaShann Selby, Eric Hempen, Jason Nascone, Marcus Sciadini, Christopher Renninger, Casey Loudermilk, Ethan Adler, Harmon Bennett, Karan Kommu, Zachary Wilhelm, Yohan Jang, Dillon O’Niell, Jan Szatkowski, Luke Lopas, Walter Virkus, Jena Robinson, Anastasiya Bahdanovich, Amy Jo Skinner, Brandon Benbow, Cora Mizimakoski, Matthew Graves, John Morellato, Jennifer Barr, Izuchukwu Ibe, Spencer Montgomery, Peter Mittwede, Caesar Alshibli, Clarence Clark, Drew Melancon, Priyanka Nehete, Giselle Hernandez, Arjun Srinath, Steven Kalandiak, Fernando Vilella-Hernandez, Shawn Boomsma, Francisco Fuster, Steven Steinlauf, Anastasiya Drandarov, Abraham Goch, Jeff Schulman, Jonathan Fausey, Jonathan Wills, Kristen Moss, Michael Holzman, A Stephen Malekzadeh, Caitlin Quigley, Kameron Rashid, Michael J Beltran, H Claude Sagi, Michael T Archdeacon, Richard T Laughlin, Theodore T Le, Jonas E Keller, Kimberly A Hasselfeld, Isaac Hale, Jenna S Hall, Logan P Lake, Paul McMillan, Ronak J Mahatme, Shawn A Moore, Todd Jaeblon, Alexander Hahn, Brent Bauer, Logan Kolakowski, Sean Meredith, Sneh Talwar, Fabio Pencle, Griffin Biedron, Matthew Patrick, Michael Talerico, Richard Vlasak, Thomas Krupko, Diana Rijo, Virginia Dykes, Joseph T Patterson, Sarah R Blumenthal, Charalampos Zalavras, Elke R Ahlmann, Mark E Fleming, Pui Yan, Isabel Ruacho, Dane Brodke, Joann Deutsche, Talia D Trapalis, Jennifer C Shatzer, David Stockton, Aresh Sepehri, Henry Broekhuyse, Kelly Lefaivre, Phillip Hache, Chloe Chong, Tiana Phi, Elizabeth Smailes, Jamal Al-Asiri, Bill Ristevski, Krishan Rajaratnam, Paul Klas, Jodi L Gallant, Kaitlyn Pusztai, J Matthew Bridger, Shayan Saiyed, David Rothberg, Justin Haller, Chukwuebuka Achebe, Garrett Oman, Zachary Funk, Katy Fu, Sandy Johnson, Alesha Scott, Bobbi Clinch, Lukas Emile Hashem, Stephen D Forro, Kristin Williams, Amber Retzlaff, David Cinats, Kyrsten Butterfield, Manuja Yogalingam, Olivia Windbiel, Mataya Lukas, John Gentile, Adam Hoffman, Andrew Burnikel, Benjamin Conover, Branum Layton, Christel Molnar, Claire Elizabeth Krohn, Emily Lewis, Geoffrey Marston, Jackson Moorefield, Jacob Eskew, Jahan Threeths, John D. (JD) Adams, Kassandra Flores, Kellen Worhacz, Lindsey Tully, Melanie Patterson, Raymond Kitziger, Richard (Trey) Gurich, Kyle Adams, Rosalynn Rice, Calleigh Brignull, Michelle Drosback, Sabrina Salley, Thomas Schaller, Sarah Pirkle, William (Sam) Mellor, Zach Reynolds, James (Mike) Miller, Lydia Roward, Allan Liew, Bradley Meulenkamp, Braden Gammon, Geoffrey Wilkin, Karl-André Lalonde, Wade Gofton, Manisha Mistry, Hoda Ghaziasgar, Gerard Chang, Philip Wolinsky, Devin S Mullin, Holly Symonds, Chelsey Recendez, Jon-Mikael Anderson, Doug Parr, Cameron Woods, Christopher Domes, Christopher Doro, David Goodspeed, Gerald Lang, Jacquelyn Dunahoe, Brandon Wilkinson, Anna van der Horst, Daniel Sheerin, Kate Spitzley, Ellie DeLoretto, Hannah College, Tessa Kirkpatrick, William Naylor, Ammar Karim, Neil Motzkin, Aaliyah Dean, Annette Taylor, Charlotte Tanner, Jessica Hummel, Carol Lin, Charles Moon, Geoffrey Marecek, John Garlich, Max Michalski, Arman Jordan, Denice Dubuclet, Michael Fernandez, Shannon O’Hara, Matthew Riedel, Michael Leslie, Motasem Salameh, Edgar Benitez, Lindsie Boerger, Devon Cormier, Grace Cortezzo, Erik Kubiak, Casey Roehr, Janel Pietryga, Karen Nelson, Robert Panganiban, Robert Bimbi, Douglas Lundy, Ajay Kanakamedala, Chinenye Nwachuku, David Ramski, Dustin Greenhill, Hithem Rahmi, James Lachman, James Sacco, Kevin Valdes, Kristofer Matullo, Nicholas Grimm, Patrick Brogle, Scott Polanksy, Kyle McFadden, Monica Hosler, Rob Van Demark III, Patrick Horrigan, Aaron Pemberton, Jennifer Lovro, John J Wixted, Edward K Rodriguez, Ishaq O Ibrahim, Paul T Appleton, Kiran J Agarwal-Harding, Michael F McTague, Julia D Aguiar, Katiri T Wagner, Augustine Saiz, Christian Bromfield, Ellen Fitzpatrick, Gillian Soles, Sean Campbell, Maya Porter, Abdel-Rahman Lawendy, Christopher Del Balso, Fatma Alqahwaji, Reem Ansari, Michael A White, Kathryn McEvoy, Katelyn Zillmer, Brody Scholl, Chase Gauthier, Christine Collins, Edward Floyd, Erik Slette, Jordan Shearer, Joseph Bruenjes, Kevin Dahl, Kevin Feltz, Kyle Muckenhirn, Kyler Hardie, Luke Hurley, Marlena Pigliacampi, Michael LaRoque, Mikayla Montgomery, Parth Vyas, Peter Bueide, Thomas Seaver, Travis Flick, Vanessa Richardson, Daniel Cunningham, Kevin Murr, Harley T Davis, Ted Tufescu, Helena Greene, Sarah Anthony, Ali Salman, John Scolaro, James Learned, Susan Demas, Brandon Lehman, Kevin Borsada, Andrew Adamczyk, Niloofar Dehghan, Stanna Calderon, Abdulkerim Gokturk, Lauren Tatman, Karen Trochez, Andres Moreno-Diaz, Juanita Velasco-Castro, Devan Kumar +395 moredoaj +2 more sourcesLong lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination. [PDF]
PLoS PathogensVaccination with radiation-attenuated sporozoites (RAS) can provide highly effective protection against malaria in both humans and mice. To extend understanding of malaria immunity and inform the development of future vaccines, we studied the protective ...Maria N de Menezes, Zhengyu Ge, Anton Cozijnsen, Stephanie Gras, Patrick Bertolino, Irina Caminschi, Mireille H Lahoud, Katsuyuki Yui, Geoffrey I McFadden, Lynette Beattie, William R Heath, Daniel Fernandez-Ruiz +11 moredoaj +2 more sources
