Results 81 to 90 of about 12,572 (254)

Anti-Amyloidogenic Properties of Some Phenolic Compounds

Biomolecules, 2015
A family of 21 polyphenolic compounds consisting of those found naturally in danshen and their analogues were synthesized and subsequently screened for their anti-amyloidogenic activity against the amyloid beta peptide (Aβ42) of Alzheimer’s disease ...
Afsaneh Porzoor, Benjamin Alford, Helmut M. Hügel, Danilla Grando, Joanne Caine, Ian Macreadie   +5 more
doaj   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy [PDF]

, 2015
published_or_final_versio
Chong, CM, Chu, IK, Cui, G, Guo, L, Hoi, MPM, Lee, SMY, Li, G, Quan, Q, Shan, L, Sun, Y, Wang, Y, Yu, P, Zhang, Z, Zhao, Y   +13 more
core   +1 more source

Orthoquinone, Cyclic, and Acyclic α‐Diketone Natural Products: From Food Applications to Pharmacotherapy

Phytochemicals in Food and Medicine, Volume 1, Issue 1, March 2026.
The orthoquinone metabolites from plants have antimicrobial, antioxidant, antiviral, cytotoxic, and anti‐inflammatory effects. ABSTRACT The structural diversity of natural products is vast and fascinating, and they have been recognized as an enormously diverse source of new lead compounds.
Hidayat Hussain, Daijie Wang, Satyajit D. Sarker, Lutfun Nahar, Nilufar Z. Mamadalieva, Jianbo Xiao   +5 more
wiley   +1 more source

Exploring the Potential Mechanism of Danshen in the Treatment of Concurrent Ischemic Heart Disease and Depression Using Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation

Natural Product Communications, 2022
Objective: This study aimed to explore the potential targets and mechanism of action of Danshen in treating concurrent ischemic heart disease (IHD) and depression using network pharmacology, molecular docking, and molecular dynamics simulation (MDS ...
Zhiyao Liu, Hailiang Huang, Ying Yu, Yuqi Jia, Xiaowen Dang, Yajie Wang, Lei Huang   +6 more
doaj   +1 more source

Effects of tanshinone on hyperandrogenism and the quality of life in women with polycystic ovary syndrome: protocol of a double-blind, placebo-controlled, randomised trial. [PDF]

, 2013
published_or_final_versio
Cong, J, Li, W, Ng, EHY, Shen, W, Wu, X, Zhang, Y, Zhou, Y   +6 more
core   +1 more source

Novel Glycyrrhizinic Acid Derivative YCY‐20 Inhibits Cerebral Ischemia/Reperfusion Induced Apoptosis via the AGE‐RAGE/MAPK Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Novel licorice‐derived compound YCY‐20 attenuates cerebral ischemia–reperfusion injury by suppressing neuronal apoptosis. Mechanistic studies reveal its neuroprotection is mediated through inhibition of the AGE‐RAGE/MAPK pathway, providing a preclinical foundation for stroke therapeutics development.
Jia Luo, Xue Qin, Jiaxin Chen, Xiushi Yu, Ziyun Liu, Jiyi Lv, Xinhui Pan, Yong Chen, Lili Wei   +8 more
wiley   +1 more source

The effect of Danshen extract on lipoprotein-associated phospholipase A2 levels in patients with stable angina pectoris: study protocol for a randomized controlled trial - the DOLPHIN study

Trials, 2017
Background Lipoprotein-associated phospholipase A2 (Lp-PLA2), a biomarker of oxidation and inflammation, has been associated with increased coronary artery disease risk.
A-Di Chen, Chun-Ling Wang, Yang Qin, Liang Tian, Li-Bin Chen, Xiao-Ming Yuan, Lin-Xiu Ma, Yu-Feng Wang, Ji-Rong Sun, Hao-Sen Wang, Neng Dai, DOLPHIN investigator group   +11 more
doaj   +1 more source

Cytochrome P450 enzyme mediated herbal drug interactions (Part 2) [PDF]

, 2014
To date, a number of significant herbal drug interactions have their origins in the alteration of cytochrome P450 (CYP) activity by various phytochemicals. Among the most noteworthy are those involving St.
Phopin, Kamonrat, Prachayasittikul, Virapong, Wanwimolruk, Sompon   +2 more
core  

Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Salvia coccinea is rich in bioactive phytochemicals, notably the flavonoid apigenin, offering strong antioxidant, anti‐inflammatory, and antimicrobial effects. By modulating inflammatory and oxidative pathways, it shows potential for managing chronic diseases.
Muhammad Usman Khalid, Muhammad Tauseef Sultan, Muhammad Maaz, Shehnshah Zafar, Anum Shoukat, Nudrat Khursheed, Matteo Bordiga, Amna Junaid   +7 more
wiley   +1 more source