Results 211 to 220 of about 9,798 (259)
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Seminars in Thoracic and Cardiovascular Surgery, 2021
The impairment of intracellular calcium homeostasis plays an essential role during ischemia-reperfusion injury. Calcium release from sarcoplasmic reticulum which is triggered by myocardial ischemia is mainly mediated by ryanodine receptors.
I. Samiotis +6 more
semanticscholar +1 more source
The impairment of intracellular calcium homeostasis plays an essential role during ischemia-reperfusion injury. Calcium release from sarcoplasmic reticulum which is triggered by myocardial ischemia is mainly mediated by ryanodine receptors.
I. Samiotis +6 more
semanticscholar +1 more source
Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes
Heart Rhythm, 2017Jonas Herting, Jan Gummert, Lars Maier
exaly +2 more sources
Der Anaesthesist, 2003
Malignant hyperthermia (MH) is a genetic, potentially life-threatening disorder of the skeletal muscle presenting during or following general anaesthesia. Trigger agents are volatile anaesthetics and depolarising muscle relaxants. Dantrolene is the only available drug for effective and specific MH therapy, which reduces significantly the mortality rate.
Frank Wappler +4 more
openaire +3 more sources
Malignant hyperthermia (MH) is a genetic, potentially life-threatening disorder of the skeletal muscle presenting during or following general anaesthesia. Trigger agents are volatile anaesthetics and depolarising muscle relaxants. Dantrolene is the only available drug for effective and specific MH therapy, which reduces significantly the mortality rate.
Frank Wappler +4 more
openaire +3 more sources
Intensive Care Medicine, 1988
In its most severe form tetanus is treated with prolonged use of neuromuscular blockade, and artificial ventilation. We report a case in which the use of dantrolene sodium shortened the period of artificial ventilation.
J Curran, A. Hutchinson, I Farquhar
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In its most severe form tetanus is treated with prolonged use of neuromuscular blockade, and artificial ventilation. We report a case in which the use of dantrolene sodium shortened the period of artificial ventilation.
J Curran, A. Hutchinson, I Farquhar
openaire +2 more sources
Synthesis and pharmacological properties of dantrolene and sodium dantrolene
Pharmaceutical Chemistry Journal, 1984AbstractDer Aldehyd (I) reagiert mit Aminohydantoin (II) zu Dantrolen (III), aus dem mit Natrium‐methylat das Natrium‐Salz (IV) erhalten wird.
R. D. Syubaev +4 more
openaire +3 more sources
British Journal of Dermatology, 1981
We describe two cases of an unusual acneiform eruption which occurred in middle aged women being treated with dantrolene for spasticity.
S.R. Saxena +3 more
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We describe two cases of an unusual acneiform eruption which occurred in middle aged women being treated with dantrolene for spasticity.
S.R. Saxena +3 more
openaire +3 more sources
Hyperkalemia after Dantrolene and Verapamil-Dantrolene Administration in Dogs
Anesthesia & Analgesia, 1988The concurrent administration of dantrolene and verapamil has the theoretical advantage of being more efficacious than dantrolene alone in the treatment of malignant hyperthermia. However, the combination has been reported to cause fatal hyperkalemia in pigs.
A. C. San Juan, K. C. Wong, J. D. Port
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Anaesthesia, 1979
A single oral dose of dantrolene (100--150 mg) given at least 2 hr pre-operatively has been found to reduce significantly the strength of muscular fasciculations, the hyperkalaemia and the incidence of muscle pains following suxamethonium (from 56 to 4%) in a series of forty-eight patients compared with controls.
openaire +4 more sources
A single oral dose of dantrolene (100--150 mg) given at least 2 hr pre-operatively has been found to reduce significantly the strength of muscular fasciculations, the hyperkalaemia and the incidence of muscle pains following suxamethonium (from 56 to 4%) in a series of forty-eight patients compared with controls.
openaire +4 more sources
Pharyngeal spasticity due to dantrolene
Journal of Clinical Pharmacy and Therapeutics, 2014Dantrolene can be combined with baclofen to better treat spasticity, but may cause muscular weakness and dysphagia. We instead describe a pharyngeal spasm due to dantrolene.A 12-year-old male received dantrolene 3 mg/kg/day in adjunct to baclofen 2 mg/kg/day, to improve spasticity.
F. Locatelli +10 more
openaire +3 more sources