Results 211 to 220 of about 9,385 (245)
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Der Anaesthesist, 2003
Malignant hyperthermia (MH) is a genetic, potentially life-threatening disorder of the skeletal muscle presenting during or following general anaesthesia. Trigger agents are volatile anaesthetics and depolarising muscle relaxants. Dantrolene is the only available drug for effective and specific MH therapy, which reduces significantly the mortality rate.
Frank Wappler +4 more
openaire +3 more sources
Malignant hyperthermia (MH) is a genetic, potentially life-threatening disorder of the skeletal muscle presenting during or following general anaesthesia. Trigger agents are volatile anaesthetics and depolarising muscle relaxants. Dantrolene is the only available drug for effective and specific MH therapy, which reduces significantly the mortality rate.
Frank Wappler +4 more
openaire +3 more sources
Synthesis and pharmacological properties of dantrolene and sodium dantrolene
Pharmaceutical Chemistry Journal, 1984AbstractDer Aldehyd (I) reagiert mit Aminohydantoin (II) zu Dantrolen (III), aus dem mit Natrium‐methylat das Natrium‐Salz (IV) erhalten wird.
R. D. Syubaev +4 more
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British Journal of Dermatology, 1981
We describe two cases of an unusual acneiform eruption which occurred in middle aged women being treated with dantrolene for spasticity.
S.R. Saxena +3 more
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We describe two cases of an unusual acneiform eruption which occurred in middle aged women being treated with dantrolene for spasticity.
S.R. Saxena +3 more
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European Review for Medical and Pharmacological Sciences, 2020
Dantrolene, an FDA approved drug to treat malignant hyperthermia and muscle spasm, has been demonstrated to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediated toxicity of host cells.
B. Jiang, S. Liang, G. Liang, H. Wei
semanticscholar +1 more source
Dantrolene, an FDA approved drug to treat malignant hyperthermia and muscle spasm, has been demonstrated to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediated toxicity of host cells.
B. Jiang, S. Liang, G. Liang, H. Wei
semanticscholar +1 more source
Intensive Care Medicine, 1988
In its most severe form tetanus is treated with prolonged use of neuromuscular blockade, and artificial ventilation. We report a case in which the use of dantrolene sodium shortened the period of artificial ventilation.
J Curran, A. Hutchinson, I Farquhar
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In its most severe form tetanus is treated with prolonged use of neuromuscular blockade, and artificial ventilation. We report a case in which the use of dantrolene sodium shortened the period of artificial ventilation.
J Curran, A. Hutchinson, I Farquhar
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Hyperkalemia after Dantrolene and Verapamil-Dantrolene Administration in Dogs
Anesthesia & Analgesia, 1988The concurrent administration of dantrolene and verapamil has the theoretical advantage of being more efficacious than dantrolene alone in the treatment of malignant hyperthermia. However, the combination has been reported to cause fatal hyperkalemia in pigs.
A. C. San Juan, K. C. Wong, J. D. Port
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Anaesthesia, 1979
A single oral dose of dantrolene (100--150 mg) given at least 2 hr pre-operatively has been found to reduce significantly the strength of muscular fasciculations, the hyperkalaemia and the incidence of muscle pains following suxamethonium (from 56 to 4%) in a series of forty-eight patients compared with controls.
openaire +4 more sources
A single oral dose of dantrolene (100--150 mg) given at least 2 hr pre-operatively has been found to reduce significantly the strength of muscular fasciculations, the hyperkalaemia and the incidence of muscle pains following suxamethonium (from 56 to 4%) in a series of forty-eight patients compared with controls.
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Pharyngeal spasticity due to dantrolene
Journal of Clinical Pharmacy and Therapeutics, 2014Dantrolene can be combined with baclofen to better treat spasticity, but may cause muscular weakness and dysphagia. We instead describe a pharyngeal spasm due to dantrolene.A 12-year-old male received dantrolene 3 mg/kg/day in adjunct to baclofen 2 mg/kg/day, to improve spasticity.
F. Locatelli +10 more
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The mechanism of action of dantrolene sodium.
The Journal of Pharmacology and Experimental Therapeutics, 1977Dantrolene sodium is thought to affect some step in the excitation-contraction coupling process. Using a point voltage clamp to determine mechanical thresholds of individual fibers of frog, rat and goat skeletal muscle preparations, we found that dantrolene both raises (moves to more positive potentials) the rheobasic potential and increases the ...
Kathleen G. Morgan, S. H. Bryant
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Pharmacokinetics and metabolism of dantrolene in horses
Journal of Veterinary Pharmacology and Therapeutics, 2011Dantrolene is a skeletal muscle relaxant used commonly in performance horses to prevent exertional rhabdomyolysis. The goal of the study reported here was to begin to characterize cytochrome P450-mediated metabolism of dantrolene in the horse and describe the pharmacokinetics of the compound, formulated as a capsule or a compounded paste formulation ...
Benjamin C. Moeller +4 more
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