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The mechanism of action of dantrolene sodium.
The Journal of Pharmacology and Experimental Therapeutics, 1977Dantrolene sodium is thought to affect some step in the excitation-contraction coupling process. Using a point voltage clamp to determine mechanical thresholds of individual fibers of frog, rat and goat skeletal muscle preparations, we found that dantrolene both raises (moves to more positive potentials) the rheobasic potential and increases the ...
Kathleen G. Morgan, S. H. Bryant
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Pharmacokinetics of dantrolene sodium in horses
Journal of Veterinary Pharmacology and Therapeutics, 1987The pharmacokinetics of dantrolene sodium were investigated in horses following both intravenous (2 mg/kg) and intragastric (4 mg/kg) administration. Two ponies also received dantrolene sodium intravenously (2 mg/kg) in a pilot study to obtain preliminary kinetic data and to determine urinary and biliary excretion of the intact drug.
M. Clark +5 more
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The Inhibition of Acetylcholinesterase by Dantrolene and Ondansetron
Drug Research, 2014A virtual screening study has suggested that the skeletal muscle relaxant, dantrolene, and the antiemetic drug, ondansetron, may act as inhibitors of the enzyme acetylcholinesterase (AChE). Based on this proposal, the current study examines the AChE inhibitory properties of these drugs.Using AChE from human erythrocytes as enzyme source, it is shown ...
Jacobus P. Petzer +2 more
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Pharmacokinetics and metabolism of dantrolene in horses
Journal of Veterinary Pharmacology and Therapeutics, 2011Dantrolene is a skeletal muscle relaxant used commonly in performance horses to prevent exertional rhabdomyolysis. The goal of the study reported here was to begin to characterize cytochrome P450-mediated metabolism of dantrolene in the horse and describe the pharmacokinetics of the compound, formulated as a capsule or a compounded paste formulation ...
Benjamin C. Moeller +4 more
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Acta Physiologica, 2019
Dantrolene interacts with ryanodine receptors in skeletal and cardiac muscle affecting sarcoplasmic reticulum calcium release. Since dantrolene is lipophilic it could also affect intra‐sarcoplasmic reticulum calcium handling proteins such as ...
Christine M. Loescher +2 more
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Dantrolene interacts with ryanodine receptors in skeletal and cardiac muscle affecting sarcoplasmic reticulum calcium release. Since dantrolene is lipophilic it could also affect intra‐sarcoplasmic reticulum calcium handling proteins such as ...
Christine M. Loescher +2 more
semanticscholar +1 more source
Pharmacokinetics of Intravenous Dantrolene in Children
Anesthesiology, 1989To determine the pharmacokinetics of iv dantrolene and its metabolites in children, ten children 2-7 yr of age scheduled for minor elective surgery, were studied. After induction of anesthesia and tracheal intubation, dantrolene (2.4 mg/kg) was administered iv over 10.2 +/- 0.83 min.
H A Strong, Jerrold Lerman, M. E. McLeod
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Effects of chronic intranasal dantrolene on nasal mucosa morphology in mice.
European Review for Medical and Pharmacological Sciences, 2022B. Jiang +5 more
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Dantrolene in Porcine Malignant Hyperthermia
Anesthesiology, 1976The effectiveness of intravenous administration of dantrolene in prevention and treatment of fulminant malignant hyperthermia (MH) initiated by halothene and succinylcholine (SCh) in genetically susceptible swine was assessed. In six animals, prior administration of dantrolene in doses of 5 mg/kg or more prevented MH, while 1 or 3 mg/kg attenuated MH ...
Richard A. Theye +2 more
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Dantrolene repurposed to treat sepsis or septic shock and COVID-19 patients.
European Review for Medical and Pharmacological Sciences, 2021H. Wei, G. Liang, R. Vera
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