Results 81 to 90 of about 1,064,868 (260)

Basic aspects of the pharmacodynamics of tolperisone, a widely applicable centrally acting muscle relaxant [PDF]

, 2014
Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in the clinical practice more than forty years ago and is still evaluated as a widely applicable compound in pathologically elevated skeletal muscle tone
Bajaj P, Dulin J, Farkas S, Fels G, Fujioka M, Funakoshi M, Funakoshi M, Gold R, Goldin A L, Hinck D, Hinck D, Hofer D, Kocsis P, Kocsis P, Kornelia Tekes, Lipták J, Luo Z, Melka A, Novales-Li P, Novales-Li P, Nádor K, Okada H, Ono H, Patel KS, Prabhoo R, Pratzel HG, Pórszász J, Quasthoff S, Quasthoff S, Rao R, Sakaue A, Sakitama K, Sakitama K, Stamenova P, Svensson P, Vora A, Zhao F   +36 more
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Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, Volume 21, Issue 29, July 24, 2025.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

Recognizing and managing a malignant hyperthermia crisis: guidelines from the European Malignant Hyperthermia Group [PDF]

, 2017
Survival from a malignant hyperthermia (MH) crisis is highly dependent on early recognition and prompt action. MH crises are very rare and an increasing use of total i.v.
Ellis, F. R., Glahn, K. P. E., Halsall, P. J., Müller, C. R., Snoeck, M. M. J., Urwyler, A., Wappler, F.   +6 more
core  

Diazonium Salts in Visible Light Photocatalysis – a Focused Overview of their Application in Continuous Flow Synthesis

ChemPhotoChem, Volume 9, Issue 6, June 2025.
The combination of continuous flow technology and visible light photocatalysis has been used to improve the safety and productivity of reactions with diazonium salts as reactive intermediates. This approach has proven to be a reliable method for various organic synthesis routes with diazonium salts under mild and well‐defined conditions.
Christoph Deckers, Thomas H. Rehm
wiley   +1 more source

Staircase in mammalian muscle without light chain phosphorylation

Brazilian Journal of Medical and Biological Research, 1999
In disuse atrophied skeletal muscle, the staircase response is virtually absent and light chain phosphorylation does not occur. The purpose of the present study was to determine if staircase could be restored in atrophied muscle with continued absence of
Rassier D.E., Tubman L.A., MacIntosh B.R.   +2 more
doaj  

Fulminant neuroleptic malignant syndrome after perioperative withdrawal of antiParkinsonian medication [PDF]

, 2017
Neuroleptic malignant syndrome is a rare complication when using neuroleptic drugs. We report the case of a patient with severe Parkinson's disease who developed neuroleptic malignant syndrome after withdrawal of his antiParkinsonian medication for ...
Pargger, H., Renggli, J.-C, Schürch, M., Stotz, M., Thümmler, D., Urwyler, A.   +5 more
core  

Systemic Primary Carnitine Deficiency Presenting With Substantia Nigra and Basal Ganglia Injury: A Case Report

JIMD Reports, Volume 66, Issue 3, May 2025.
ABSTRACT Systemic primary carnitine deficiency (SPCD) is a rare congenital fatty acid metabolism disorder causing impaired β‐oxidation and energy production, leading to hypoglycemia, metabolic encephalopathy, and sudden death. Early diagnosis and treatment, including L‐carnitine supplementation and fasting avoidance, can improve prognosis.
Tomoki Saito, Kento Soma, Mai Kashisaka, Kiiko Iketani, Masaaki Matsumoto, Takuya Ueda, Masahiro Nishiyama, Azusa Maruyama, Ryosuke Nakai, Hiroshi Sakihama, Hiroshi Kurosawa, Naoya Morisada, Hironori Kobayashi, Kayo Ozaki   +13 more
wiley   +1 more source

Molecular genetic analysis for malignant hyperthermia : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry [PDF]

, 2004
Malignant hyperthermia (MH) is a rare pharmacogenetic disorder in humans caused by inhalational general anaesthetics and depolarising muscle relaxants. An MH reaction shows abnormal calcium homeostasis in skeletal muscle leading to a hypermetabolic state
Sato, Keisaku
core  

Mitochondria regulate inositol triphosphate‐mediated Ca2+ release triggered by voltage‐dependent Ca2+ entry in resistance arteries

The Journal of Physiology, Volume 603, Issue 10, Page 2959-2978, 15 May 2025.
Abstract figure legend Proposed mechanism of regulation of mitochondria on VDCCs mediated Ca2+ signals in smooth muscle cells. Depolarization of the plasma membrane induces Ca2+ influx via L‐type VDCCs that produces a steady elevation in Ca2+ and activates IP3Rs to evoke repetitive Ca2+ release events from the intracellular Ca2+ store.
Xun Zhang, Charlotte Buckley, Matthew D. Lee, Susan Chalmers, Calum Wilson, John G. McCarron   +5 more
wiley   +1 more source

The Neuroleptic Malignant Syndrome: Do we Know Enough? [PDF]

, 2011
The Neuroleptic Malignant Syndrome (NMS) is a potentially grave adverse reaction to oral or parenteral neuroleptic therapy that may be an underdiagnosed and easily overlooked clinical problem.
Ali, MD, Ali Hassan M.
core   +1 more source