Basic aspects of the pharmacodynamics of tolperisone, a widely applicable centrally acting muscle relaxant [PDF]
, 2014 Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in the clinical practice more than forty years ago and is still evaluated as a widely applicable compound in pathologically elevated skeletal muscle tone
Bajaj P +36 more
core +1 more source
Staircase in mammalian muscle without light chain phosphorylation
Brazilian Journal of Medical and Biological Research, 1999 In disuse atrophied skeletal muscle, the staircase response is virtually absent and light chain phosphorylation does not occur. The purpose of the present study was to determine if staircase could be restored in atrophied muscle with continued absence of
Rassier D.E. +2 more
doaj
Fulminant neuroleptic malignant syndrome after perioperative withdrawal of antiParkinsonian medication [PDF]
, 2017 Neuroleptic malignant syndrome is a rare complication when using neuroleptic drugs. We report the case of a patient with severe Parkinson's disease who developed neuroleptic malignant syndrome after withdrawal of his antiParkinsonian medication for ...
Pargger, H. +5 more
core
Molecular genetic analysis for malignant hyperthermia : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry [PDF]
, 2004 Malignant hyperthermia (MH) is a rare pharmacogenetic disorder in humans caused by inhalational general anaesthetics and depolarising muscle relaxants. An MH reaction shows abnormal calcium homeostasis in skeletal muscle leading to a hypermetabolic state
Sato, Keisaku
core
British Journal of Pharmacology, Volume 182, Issue 3, Page 564-580, February 2025.Abstract Background and Purpose Botulinum neurotoxin type A1 (BoNT/A) is one of the most potent neurotoxins known. At the same time, it is also one of the safest therapeutic agents used for the treatment of several human disorders and in aesthetic medicine.
Mickaël Machicoane +9 more
wiley +1 more source
The Neuroleptic Malignant Syndrome: Do we Know Enough? [PDF]
, 2011 The Neuroleptic Malignant Syndrome (NMS) is a potentially grave adverse reaction to oral or parenteral neuroleptic therapy that may be an underdiagnosed and easily overlooked clinical problem.
Ali, MD, Ali Hassan M.
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CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia [PDF]
, 2013 Induced pluripotent stem cells (iPSC) offer a unique opportunity for developmental studies, disease modeling and regenerative medicine approaches in humans.
Avelino-Cruz, JE +11 more
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Efficacy of Dantrolene Sodium in Management of Tetanus in Children
Journal of the Royal Society of Medicine, 1986 The effectiveness of dantrolene sodium in controlling tetanic spasms was evaluated in 21 children (aged 4 days-13 years) with tetanus. These dantrolene-treated patients were compared with an historical control group of 26 children previously treated for tetanus by traditional means at the same institution.
M E Lacy, M A Bender, O R Aguilar Bernal
openaire +3 more sources
Study on contraction and relaxation of experimentally denervated and immobilized muscles: Comparison with dystrophic muscles [PDF]
The contraction-relaxation mechanism of experimentally denervated and immobilized muscles of the rabbit is examined. Results are compared with those of human dystrophic muscles, in order to elucidate the role and extent of the neurotrophic factor, and ...
Hazama, R. +4 more
core +1 more source