Results 61 to 70 of about 4,970 (234)
Heart Failure: Epidemiology, Pathophysiology, and Management
MedComm, Volume 7, Issue 3, March 2026.This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan +9 more
wiley +1 more source
Fulminant neuroleptic malignant syndrome after perioperative withdrawal of antiParkinsonian medication [PDF]
, 2017 Neuroleptic malignant syndrome is a rare complication when using neuroleptic drugs. We report the case of a patient with severe Parkinson's disease who developed neuroleptic malignant syndrome after withdrawal of his antiParkinsonian medication for ...
Pargger, H. +5 more
core
Chemical Biology &Drug Design, Volume 107, Issue 3, March 2026.The HscA–HscB–IscU system functions in iron–sulfur (Fe‐S) cluster biogenesis in bacteria and fungi, including pathogenic strains. Here, we describe a high‐throughput screen (HTS) to measure inorganic phosphate release from the ATPase HscA within this reconstituted, multi‐protein complex.
Arielle Shkedi +5 more
wiley +1 more source
Role of CA2+/calmodulin on ethanol neurobehavioral effects [PDF]
, 2014 Rationale. The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors.
Baliño, Pablo +2 more
core +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin +14 more
wiley +1 more source
Advanced Science, Volume 13, Issue 3, 14 January 2026.Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang +7 more
wiley +1 more source
Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts. [PDF]
, 2015 AIMS: Cardiac ryanodine receptor mutations are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), and some, including RyR2-P2328S, also predispose to atrial fibrillation.
Chandrasekharan, KH +7 more
core +2 more sources
Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan +6 more
wiley +1 more source