Molecular genetic analysis for malignant hyperthermia : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry [PDF]
, 2004 Malignant hyperthermia (MH) is a rare pharmacogenetic disorder in humans caused by inhalational general anaesthetics and depolarising muscle relaxants. An MH reaction shows abnormal calcium homeostasis in skeletal muscle leading to a hypermetabolic state
Sato, Keisaku
core
Basic aspects of the pharmacodynamics of tolperisone, a widely applicable centrally acting muscle relaxant [PDF]
, 2014 Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in the clinical practice more than forty years ago and is still evaluated as a widely applicable compound in pathologically elevated skeletal muscle tone
Bajaj P +36 more
core +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source
Antidote Stocking at Hospitals in North Palestine [PDF]
, 2007 Objective: The purpose of this study was to determine the availability and adequacy of antidote stocking at hospitals in north Palestine based on published guidelines for antidote stocking.
Al-Jabi W, Samah +3 more
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Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication [PDF]
, 2014 Paraoxon (POX) is an active metabolite of organophosphate (OP) pesticide parathion that has been weaponized and used against civilian populations. Exposure to POX produces high mortality.
Blair, Robert E. +4 more
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Recognizing and managing a malignant hyperthermia crisis: guidelines from the European Malignant Hyperthermia Group [PDF]
, 2017 Survival from a malignant hyperthermia (MH) crisis is highly dependent on early recognition and prompt action. MH crises are very rare and an increasing use of total i.v.
Ellis, F. R. +6 more
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Dantrolene corrects cellular disease features of Darier disease and may be a novel treatment
EMBO Molecular MedicineDarier disease (DD) is a rare severe acantholytic skin disease caused by mutations in the ATP2A2 gene that encodes for the sarco/endoplasmic reticulum calcium ATPase isoform 2 (SERCA2).
Matthew Hunt +16 more
doaj +1 more source
Characterization of Transepithelial Potential Oscillations in the \u3cem\u3eDrosophila\u3c/em\u3e Malpighian Tubule [PDF]
, 2001 The Malpighian tubule of Drosophila melanogaster is a useful model system for studying the regulation of epithelial ion transport. In acutely isolated tubules, the transepithelial potential (TEP) undergoes large oscillations in amplitude with a period of
Blumenthal, Edward M
core +1 more source
Effect of intravenous anesthetic propofol on synaptic vesicle exocytosis at the frog neuromuscular junction [PDF]
, 2014 Aim: To investigate the presynaptic effects of propofol, a short-acting intravenous anesthetic, in the frog neuromuscular junction. Methods: Frog cutaneous pectoris nerve muscle preparations were prepared.
Fonseca, Matheus de Castro +4 more
core +1 more source
Complex management of a patient with refractory primary erythromelalgia lacking a SCN9A mutation
Journal of Pain Research, 2017 Sarah A Low,1 Wendye Robbins,2,3 Vivianne L Tawfik2 1Department of Internal Medicine, Banner University Medical Center, University of Arizona College of Medicine, Tucson, AZ, 2Department of Anesthesiology, Perioperative & Pain Medicine, Stanford ...
Low SA, Robbins W, Tawfik VL
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