Results 51 to 60 of about 4,970 (234)

The medical management of cerebral palsy [PDF]

, 2016
Medical management of cerebral palsy is a complex issue that should be undertaken with the overall aim to improve comfort, function in every day life, self confidence, participation and independence. Although the main focus is commonly the motor disorder,
Kurian, MA, Smith, M
core   +1 more source

Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting GluN2B subunits: implications for synaptic plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Astrocyte‐derived lactate enhances neuronal NMDA receptor (NMDAR) function and synaptic plasticity through a redox‐ and CaMKII‐dependent mechanism. Lactate enters neurons via monocarboxylate transporters (MCTs) and is oxidized by lactate dehydrogenase (LDH) to pyruvate, generating NADH and increasing the intracellular NADH/NAD ...
Hubert Fiumelli, Gabriel Herrera‐López, Fouad Lemtiri‐Chlieh, Lorène Mottier, John Girgis, Carine Ben‐Adiba, Pascal Jourdain, Nicolò Carrano, Hanan Mahmood, Amanda Ooi, Stefan T. Arold, Monica Di Luca, Fabrizio Gardoni, Pierre J. Magistretti   +13 more
wiley   +1 more source

Effects of extracellular Ca++, K+, and Na+ on cone and retinal pigment epithelium retinomotor movements in isolated teleost retinas. [PDF]

, 1984
We have examined the effects of changes in extracellular ionic composition on cone and retinal pigment epithelium (RPE) retinomotor movements in cultured isolated teleost retinas.
BURNSIDE, Beth, Dearry, A
core   +4 more sources

Safe and Sustainable by Design (SSbD) Synthesis of Food and Personal Care Ingredients by Mechanochemistry

ChemSusChem, Volume 19, Issue 9, 14 May 2026.
A Safe and Sustainable by Design (SSbD) mechanochemical approach was used to prepare a marketed sweetener from a biomass derivative used in flavoring industry. A personal care ingredient was also synthesized. The study also evaluated and compared the reactivity in of polymeric jars with that in of common conventional stainless steel or and zirconium ...
Rubén Solórzano‐Rodríguez, Nicolas Fantozzi, Andrea Casagrande, Christos M. Chatzigiannis, Corentin Bordier, Pietro Rando, Evelina Colacino   +6 more
wiley   +1 more source

Computational analysis of calcium signaling and membrane electrophysiology in cerebellar Purkinje neurons associated with ataxia [PDF]

, 2012
BACKGROUND: Mutations in the smooth endoplasmic reticulum (sER) calcium channel Inositol Trisphosphate Receptor type 1 (IP3R1) in humans with the motor function coordination disorders Spinocerebellar Ataxia Types 15 and 16 (SCA15/16) and in a ...
Leslie M Loew, Sherry-Ann Brown
core   +2 more sources

2025 Consensus Clinical Management Guidelines for Niemann‐Pick Disease Type C

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT In 2018, the International Niemann‐Pick Disease Alliance (INPDA) and the International Niemann‐Pick Disease Registry (INPDR) developed and published comprehensive clinical management guidelines to support inclusive and standardized care pathways in Niemann‐Pick disease type C (NPC)—an ultra‐rare, autosomal recessive, neurovisceral lysosomal ...
Tarekegn Hiwot, Forbes D. Porter, Tatiana Bremova‐Ertl, Uma Ramaswami, Caroline Hastings, Bénédicte Héron, Justin Hopkin, Joella Melville, Hernan Amartino, Mireia del Toro, Federica Deodato, Fatih Ezgü, Paul Gissen, James B. Gibson, Can Ficicioglu, Roberto Giugliani, Orna Staretz‐Chacham, Frances Platt, Nathalie Guffon, Kristina Julich, Nikola Kresojević, Anna Lehman, Yann Nadjar, Susanne A. Schneider, Simon Jones, Eugen Mengel, Michel Tchan, Mark Walterfang, Ozlem Goker‐Alpan, Charlotte Dawson, Sandra Cowie, Toni Mathieson, Elizabeth Berry‐Kravis, Marc C. Patterson   +33 more
wiley   +1 more source

Ryanodine Receptors Contribute to the Induction of Nociceptive Input-Evoked Long-Term Potentiation in the Rat Spinal Cord Slice [PDF]

, 2010
Background Our previous study demonstrated that nitric oxide (NO) contributes to long-term potentiation (LTP) of C-fiber-evoked field potentials by tetanic stimulation of the sciatic nerve in the spinal cord in vivo.
Long-Zhen Cheng, Ning Lü, Yu-Qiu Zhang, Zhi-Qi Zhao   +3 more
core   +2 more sources

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Electroacupuncture for Decorticate Rigidity of the Upper Limbs in a Patient with Anoxic Brain Damage

Case Reports in Medicine, 2013
Decorticate rigidity is a type of abnormal posturing that can make it difficult to move a patient and to change the patient’s position to prevent a decubitus ulcer. This condition poses a latent risk of bed sores.
WooSang Jung, SeungWon Kwon, SeongUk Park, SangKwan Moon, JungMi Park, ChangNam Ko, KiHo Cho   +6 more
doaj   +1 more source

Malignant hyperthermia

Orphanet Journal of Rare Diseases, 2007
Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine ...
Pollock Neil, James Danielle, Davis Mark, Rosenberg Henry, Stowell Kathryn   +4 more
doaj   +1 more source