Results 31 to 40 of about 4,970 (234)

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3 [PDF]

open access: yes, 2008
Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine expansion in ataxin-3 (SCA3, MJD1) protein.
Bezprozvanny, I   +7 more
core   +1 more source

Selenium alleviates cadmium-induced oxidative stress, endoplasmic reticulum stress, and apoptosis in L8824 cells

open access: yesEcotoxicology and Environmental Safety, 2023
Cadmium (Cd) is a toxic pollutant in industrial production that induces organ damage and apoptosis, While, selenium (Se) has the biological function of antagonizing Cd toxicity.
Tingting Zhang   +4 more
doaj   +1 more source

Hepatitis from dantrolene sodium. [PDF]

open access: yesGut, 1979
The clinical course and histological changes in the liver during a presumed adverse reaction to the drug dantrolene sodium are described in four patients. After a typical prodrome one developed a moderately severe hepatitis-like illness. Another also had a prodrome but never became jaundiced.
S P, Wilkinson, B, Portmann, R, Williams
openaire   +2 more sources

Treatments for spasticity and pain in multiple sclerosis: a systematic review [PDF]

open access: yes, 2003
Objectives: To identify the drug treatments currently available for the management of spasticity and pain in multiple sclerosis (MS), and to evaluate their clinical and cost-effectiveness.
Beard, S.M., Hunn, A., Wight, J.
core   +1 more source

Malignant hyperthermia [PDF]

open access: yesKorean Journal of Anesthesiology, 2012
Malignant hyperthermia (MH) is an uncommon, life-threatening pharmacogenetic disorder of the skeletal muscle. It presents as a hypermetabolic response in susceptible individuals to potent volatile anesthetics with/without depolarizing muscle relaxants ...
Dong-Chan Kim
doaj   +1 more source

Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper [PDF]

open access: yes, 2016
BACKGROUND AND OBJECTIVES: Treatment of spasticity poses a major challenge given the complex clinical presentation and variable efficacy and safety profiles of available drugs. We present a systematic review of the pharmacological treatment of spasticity
Comi, G   +8 more
core   +1 more source

Delayed-Onset Malignant Hyperthermia in Association with Rocuronium Use [PDF]

open access: yes, 2012
Purpose Two cases of malignant hyperthermia suspected to be related to the use of a nondepolarizing neuromuscular blocker are reported. Summary A pharmacogenetic disorder that may occur in as many as 1 in 3000 anesthesia procedures, malignant ...
Beggs, Ashton E.   +2 more
core   +2 more sources

Carisoprodol withdrawal syndrome resembling neuroleptic malignant syndrome: Diagnostic dilemma

open access: yesJournal of Anaesthesiology Clinical Pharmacology, 2016
Soma (Carisoprodol) is N-isopropyl-2 methyl-2-propyl-1,3-propanediol dicarbamate; a commonly prescribed, centrally acting skeletal muscle relaxant. Neuroleptic malignant syndrome (NMS) is a potentially life-threatening adverse effect of antipsychotic ...
Gunchan Paul   +2 more
doaj   +1 more source

Cooling and hemodynamic management in heatstroke: practical recommendations [PDF]

open access: yes, 2007
INTRODUCTION:Although rapid cooling and management of circulatory failure are crucial to the prevention of irreversible tissue damage and death in heatstroke, the evidence supporting the optimal cooling method and hemodynamic management has yet to be ...
Abderrezak Bouchama   +2 more
core   +1 more source

In vivo Ca2+ dynamics induced by Ca2+ injection in individual rat skeletal muscle fibers [PDF]

open access: yes, 2017
Citation: Wakizaka, M., Eshima, H., Tanaka, Y., Shirakawa, H., Poole, D. C., & Kano, Y. (2017). In vivo Ca2+ dynamics induced by Ca2+ injection in individual rat skeletal muscle fibers. Physiological Reports, 5(5), 10.
Eshima, H.   +5 more
core   +1 more source

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