Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy
Case Reports in Anesthesiology, 2020 Malignant hyperthermia is a rare pharmacogenetic disorder triggered by depolarizing muscle relaxant and potent volatile anesthetic agents. An MH crisis is an emergency and life-threatening event requiring early recognition and prompt management ...
Warangkana Lapisatepun +1 more
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Dantrolene sodium and ‘skinned’ muscle fibres [PDF]
Nature, 1975 LYDIA BROCKLEHURST
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Malignant Syndrome in Parkinson Disease Similar to Severe Infection [PDF]
Korean Journal of Critical Care Medicine, 2017 A 70-year-old woman with Parkinson disease was admitted to the emergency department with altered consciousness, fever and convulsive movements without experiencing withdrawal from antiparkinsonian medication.
Dong Hun Lee +2 more
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Calcium Homeostasis in Myogenic Differentiation Factor 1 (MyoD)-Transformed, Virally-Transduced, Skin-Derived Equine Myotubes [PDF]
, 2014 Dysfunctional skeletal muscle calcium homeostasis plays a central role in the pathophysiology of several human and animal skeletal muscle disorders, in particular, genetic disorders associated with ryanodine receptor 1 (RYR1) mutations, such as malignant
A Hovnanian +75 more
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Dantrolene sodium and dystrophia myotonica [PDF]
Anaesthesia, 1984 Summary A patient with dystrophia myotonica was given dantrolene sodium to try to provide muscle relaxation during a cholecystectomy. Dantrolene was used as it is accepted that the drug has a place in the control of spasticity and also causes muscle relaxation, whereas conventional muscle relaxants are unable to control myotonia of ...
D C, Phillips +3 more
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Difficulties in management of malignant hyperthermia in a rural set up of a developing country
Medical Journal of Dr. D.Y. Patil University, 2014 Lack of availability of dantrolene sodium causes difficulty in management of malignant hyperthermia in different parts of India. We hereby report the case of a seven-year-old girl child who developed malignant hyperthermia and expired in spite of all ...
Debashis Saha +3 more
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Basal ryanodine receptor activity suppresses autophagic flux [PDF]
, 2017 The inositol 1,4,5-trisphosphate receptors (IP3Rs) and intracellular Ca2+ signaling are critically involved in regulating different steps of autophagy, a lysosomal degradation pathway.
Bannai, Hiroko +9 more
core +2 more sources
Pharmacological Blockade of the Calcium Plateau Provides Neuroprotection Following Organophosphate Paraoxon Induced Status Epilepticus in Rats [PDF]
, 2016 Organophosphate (OP) compounds which include nerve agents and pesticides are considered chemical threat agents. Currently approved antidotes are crucial in limiting OP mediated acute mortality.
Ajdacic-Gross +43 more
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A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI [PDF]
, 2013 BACKGROUND: Acute kidney injury (AKI) is a frequent condition in hospitalised patients undergoing major surgery or the critically ill and is associated with increased mortality.
Delles, C. +6 more
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Lumbriculus variegatus: A novel organism for in vivo pharmacology education
Pharmacology Research & Perspectives, 2021 Pharmacology graduates require an understanding of both in vitro and in vivo drug responses but there has been a decline in animal use in pharmacology education over the last 30 years. To address this, we present the novel invertebrate model, Lumbriculus
Aidan Seeley +3 more
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