Results 121 to 130 of about 195,859 (249)

A genetic risk score based on BCL11A and HBS1L‐MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients

British Journal of Haematology, EarlyView.
Summary Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co‐inheritance of genetic variants that regulate globin expression.
Gabriela S. Arcanjo, Alexsandro P. Silva, Madi V. Diniz, Igor F. Domingos, Diego A. Pereira‐Martins, Amanda B. Araújo, Talita S. S. França, Ana C. Anjos, Aderson S. Araujo, Edis Belini‐Junior, Sara T. O. Saad, Fernando F. Costa, Antonio R. Lucena‐Araujo, Marcos André C. Bezerra   +13 more
wiley   +1 more source

Diabetic foot disease carries an intrinsic high risk of mortality and other severe outcomes in type 2 diabetes: a propensity score-matched retrospective population-based study

Cardiovascular Diabetology
Background To evaluate the association between diabetic foot disease (DFD) and the incidence of fatal and non-fatal events in individuals with type 2 diabetes (T2DM) from primary-care settings. Methods We built a cohort of people with a first DFD episode
Bogdan Vlacho, Magdalena Bundó, Judit Llussà, Jordi Real, Manel Mata-Cases, Xavier Cos, Diana Tundidor, Francesco Zaccardi, Kamlesh Khunti, Edward B. Jude, Josep Franch-Nadal, Dídac Mauricio   +11 more
doaj   +1 more source

Variable electrophysiology before and after block of the two delayed rectifier potassium channels in groups of isolated rabbit ventricular cells

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Between‐cell differences in ventricular cardiomyocyte action potential duration (APD) and responses to ion channel block may contribute to pro‐arrhythmic dispersion of myocardial repolarisation. This study quantifies between‐cell physiological and pharmacological variability in the rabbit left ventricle (LV) and uses ...
Rebecca J. Gilchrist, Muhamad Hifzhudin Noor Aziz, Francis L. Burton, Radostin D. Simitev, Rachel C. Myles, Godfrey L. Smith   +5 more
wiley   +1 more source

The Molecular Diagnosis of Myopathies: Integrating Genomic, Proteomic, and Pathological Insights Toward Precision Medicine

Clinical Genetics, EarlyView.
Advances in genomic, proteomic, and transcriptomic technologies are transforming the diagnosis of genetic myopathies. When integrated with traditional muscle pathology, multi‐omics approaches improve diagnostic yield, clarify disease mechanisms, and support more precise, mechanism‐based therapeutic strategies for patients with neuromuscular disorders ...
Ludmila Alem, Denise de Abreu Pereira, Katia Carneiro   +2 more
wiley   +1 more source

Assessment of Different Technologies in the Fabrication of 3D Printed Tooth Models for Dental Education

European Journal of Dental Education, EarlyView.
ABSTRACT Background 3D printing has emerged as a practical method for fabricating customisable, accurate and affordable dental training models. Numerous 3D printing technologies exist, though there is no standardised comparison to inform their implementation in dental education.
Samuel Bereza, Danilo Carluccio, James Novak, Darius Khadembaschi, Martin Batstone, Saso Ivanovski   +5 more
wiley   +1 more source

Flow‐controlled expiration improves gas exchange in anaesthetised horses undergoing orthopaedic surgery

Equine Veterinary Journal, EarlyView.
Abstract Background Flow‐controlled expiration (FLEX) has been shown to significantly enhance oxygenation in horses under laboratory conditions. Objective This study aims to corroborate these findings by evaluating the effects of FLEX on gas exchange in a randomised clinical trial involving a large population of clinical horses undergoing orthopaedic ...
Klaus Hopster, Joao Henrique Neves Soares, David Levine, Kyla Ortved, Bernd Driessen, Joaquin Araos   +5 more
wiley   +1 more source

Toward a Functional Cure for Chronic Hepatitis B: Current Landscape and Future Directions in Japan

Hepatology Research, EarlyView.
Hepatitis B is a viral liver infection that can become chronic, increasing the risk of developing liver cancer and liver failure. Because current treatments rarely cure these problems, researchers are now focusing on a functional cure in which the virus becomes undetectable in blood and stays that way, even after the treatment ends.
Yutaka Handa, Ethan Yichen Lee, Yasuhito Tanaka   +2 more
wiley   +1 more source

The Efficacy of Intracanal Medicaments Within the Regenerative Endodontic Procedures on Permanent Necrotic Immature Teeth: Systematic Review and Naïve Indirect‐Comparison Meta‐Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Objectives The objectives of this study were to estimate and compare the 1‐year clinical success rates of triple antibiotic paste (TAP), double antibiotic paste (DAP), calcium hydroxide (CH) within regenerative endodontic procedures (REPs) on permanent necrotic immature teeth.
Mario Alovisi, Paolo G. Arduino, Stefano Petti   +2 more
wiley   +1 more source

Correlates of Mortal Distress Among Healthcare Staff in Hospitals: A Systematic Review and Meta‐Analysis

Journal of Advanced Nursing, EarlyView.
ABSTRACT Background Mortal distress encompasses emotional, cognitive, physical and behavioural responses to death and dying among healthcare staff who frequently encounter mortality in hospital settings. Healthcare workers often experience heightened levels of mortal distress due to their regular exposure to patient deaths, which can negatively impact ...
Joy Juan Wang, Jing Ning, Jiu Li Xu, Yong Hao Ng, Ernest Wing‐Tak Chui   +4 more
wiley   +1 more source

Impact of Curarization on Pentaspline Catheter Stability During Pulsed‐Field Pulmonary Vein Ablation

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Pulsed field ablation (PFA) is effective for pulmonary vein isolation (PVI), but phrenic nerve stimulation during applications may induce diaphragmatic contractions and destabilize catheter positioning. This study evaluated whether neuromuscular blockade improves catheter stability.
Aymeric Menet, Suzanne Charkaluk, William Escande, Antoine Noel, Outteryck François, Corentin Chaumont, Valentine Pecriaux, Jeremy Layec, Marie Decroocq, Yves Guyomar, Vincent Colas, Sylvestre Maréchaux, Frederic Anselme, Guillaume Viart   +13 more
wiley   +1 more source