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Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals [PDF]
International Journal of Molecular Sciences, 2018 Death associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine kinase; its main function is to regulate cell death. DAPK family proteins consist of DAPK1, DAPK2, DAPK3, DAPK-related apoptosis-inducing protein kinases (DRAK)-1 and DRAK-2. In this review, we discuss the roles and regulatory mechanisms of DAPK family members and
Mohamed Elbadawy +2 more
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Death Associated Protein Kinases: Molecular Structure and Brain Injury [PDF]
International Journal of Molecular Sciences, 2013 Perinatal brain damage underlies an important share of motor and neurodevelopmental disabilities, such as cerebral palsy, cognitive impairment, visual dysfunction and epilepsy. Clinical, epidemiological, and experimental studies have revealed that factors such as inflammation, excitotoxicity and oxidative stress contribute considerably to both white ...
Claire Thornton +2 more
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Regulatory Non-coding RNAs for Death Associated Protein Kinase Family [PDF]
Frontiers in Molecular Biosciences, 2021 The death associated protein kinases (DAPKs) are a family of calcium dependent serine/threonine kinases initially identified in the regulation of apoptosis. Previous studies showed that DAPK family members, including DAPK1, DAPK2 and DAPK3 play a crucial
Qingshui Wang +6 more
doaj +3 more sources
Frontiers in Bioscience-Landmark, 2022 p38 MAPK (mitogen-activated protein kinases) family proteins (α, β, γ and δ) are key inflammatory kinases and play an important role in relaying and processing intrinsic and extrinsic signals in response to inflammation, stress, and oncogene to regulate ...
Jian-Zhong Qin +3 more
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Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporter. [PDF]
PLoS ONE, 2010 Death-Associated Protein Kinase (DAPK) is a member of the Ca2+/calmodulin regulated serine/threonine protein kinases. Its biological function has been associated with induced cell death, and in vivo use of selective small molecule inhibitors of DAPK ...
Michael Zimmermann +13 more
doaj +1 more source
Scaffold Role of DUSP22 in ASK1-MKK7-JNK Signaling Pathway. [PDF]
PLoS ONE, 2016 Mitogen-activated protein kinases (MAPKs) are involved in a variety of intracellular events such as gene expression, cell proliferation, and programmed cell death.
Anna Ju +8 more
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Frontiers in Cell and Developmental Biology, 2020 Ewing sarcoma (ES) is a rare, highly aggressive, bone, or soft tissue-associated tumor. Although this sarcoma often responds well to initial chemotherapy, 40% of the patients develop a lethal recurrence of the disease, with death recorded in 75–80% of ...
Wook Jin
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Regulation of Inflammatory Cell Death by Phosphorylation
Frontiers in Immunology, 2022 Cell death is a necessary event in multi-cellular organisms to maintain homeostasis by eliminating unrequired or damaged cells. Currently, there are many forms of cell death, and several of them, such as necroptosis, pyroptosis and ferroptosis, even ...
Wen Xu, Yi Huang
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Frontiers in Molecular Biosciences, 2022 As a member of the death-associated protein kinase family of serine/threonine kinases, the STK17B has been associated with diverse diseases such as hepatocellular carcinoma.
Chang Liu +6 more
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miR-181 interacts with signaling adaptor molecule DENN/MADD and enhances TNF-induced cell death. [PDF]
PLoS ONE, 2017 MicroRNAs are small noncoding RNAs, which regulate the expression of protein coding transcripts through mRNA degradation or translational inhibition. Numerous reports have highlighted the role of miRNAs in regulating cell death pathways including the ...
Samira Ghorbani +5 more
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