Death Associated Protein Kinase 1 (DAPK1): A Regulator of Apoptosis and Autophagy [PDF]
Frontiers in Molecular Neuroscience, 2016 Death-Associated Protein Kinase 1 (DAPK1) belongs to a family of five serine/threonine (Ser/Thr) kinases that possess tumor suppressive function and also mediate a wide range of cellular processes, including apoptosis and autophagy. The loss and gain-of-function of DAPK1 is associated with various cancer and neurodegenerative diseases respectively.
Singh, Pratibha +2 more
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Mechanism of activation of NDR protein kinase by the HMOB1 protein [PDF]
, 2005 Serine/threonine kinases of the nuclear Dbf2-related (NDR) family are highly conserved throughout the eukaryotic world. Members of this kinase family are implicated in various aspects of the regulation of cell division and cell morphology. It has been
Bichsel, Samuel J.
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Mammalian NDR kinases : tumor suppressors with essential functions in embryonic development [PDF]
, 2011 NDR kinases are highly conserved from yeast to man. Loss-of-function models of Ndr homologs in yeast and fly demonstrate essential functions of the respective kinases.
Schmitz-Rohmer, Debora
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Death-associated Protein Kinase Is Activated by Dephosphorylation in Response to Cerebral Ischemia [PDF]
Journal of Biological Chemistry, 2005 Death-associated protein kinase (DAPK) is a calcium calmodulin-regulated serine/threonine protein kinase involved in ischemic neuronal death. In situ hybridization experiments show that DAPK mRNA expression is up-regulated in brain following a global ischemic insult and down-regulated in ischemic tissues after focal ischemia. DAPK is inactive in normal
Mehrdad, Shamloo +5 more
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Molecular insights into the regulatory interactions of Dystrophia myotonica protein kinase [PDF]
, 2006 Dystrophia Myotonica Protein Kinase (DMPK) is the defining member of a family of complex, multidomain kinases of major biomedical relevance. These kinases are characterized by a highly conserved catalytic domain and a coiled-coil motif (CC) involved in ...
Garcia, Pilar
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The role of BRI1-associated kinase 1 (BAK1) in the regulation of plant innate immunity : functional and genetic characterization of BAK1 overexpression in Arabidopsis thaliana [PDF]
, 2014 The role of BRI1-ASSOCIATED KINASE 1 (BAK1) in the regulation of plant innate immunity: functional and genetic characterization of BAK1 overexpression in Arabidopsis thaliana SUMMARY BAK1 (BRI1-ASSOCIATED KINASE 1) is an intensively studied member ...
Kiss-Papp, Márta
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Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance [PDF]
Cell Cycle, 2012 Anti-EGFR therapy is among the most promising molecular targeted therapies against cancer developed in the past decade. However, drug resistance eventually arises in most, if not all, treated patients. Emerging evidence has linked epigenetic changes, such as DNA methylation at CpG islands, to the development of resistance to multiple anticancer drugs ...
Takenori, Ogawa +12 more
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Exploring downstream pathways of aberrantly activated kinases for targeted leukemia therapy [PDF]
, 2008 Genetic alterations resulting in uncontrolled protein tyrosine kinases (PTKs) activity are frequently found in leukemia and in human solid cancers. Although the development of small molecule kinase inhibitors has revolutionized therapy for PTKinduced ...
Gasser, Christelle
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Death-Associated Protein Kinase-Related Protein 1, a Novel Serine/Threonine Kinase Involved in Apoptosis [PDF]
Molecular and Cellular Biology, 2000 In this study we describe the identification and structure-function analysis of a novel death-associated protein (DAP) kinase-related protein, DRP-1. DRP-1 is a 42-kDa Ca(2+)/calmodulin (CaM)-regulated serine threonine kinase which shows high degree of homology to DAP kinase.
B, Inbal +4 more
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Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo [PDF]
, 2004 <b>Background</b> From in vitro studies, it has become clear that several signaling cascades are involved in angiotensin II-induced cellular hypertrophy.
Martens Fabrice MAC +23 more
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