Results 21 to 30 of about 12,734,425 (305)

Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance [PDF]

Cell Cycle, 2012
Anti-EGFR therapy is among the most promising molecular targeted therapies against cancer developed in the past decade. However, drug resistance eventually arises in most, if not all, treated patients. Emerging evidence has linked epigenetic changes, such as DNA methylation at CpG islands, to the development of resistance to multiple anticancer drugs ...
Takenori, Ogawa, Thomas E, Liggett, Anatoliy A, Melnikov, Constance L, Monitto, Daniela, Kusuke, Kiyoto, Shiga, Toshimitsu, Kobayashi, Akira, Horii, Aditi, Chatterjee, Victor V, Levenson, Wayne M, Koch, David, Sidransky, Xiaofei, Chang   +12 more
openaire   +2 more sources

Survival-Promoting Activity of Inhibitors of Cyclin-Dependent Kinases on Primary Neurons Correlates with Inhibition of c-Jun Kinase-1

Neurobiology of Disease, 1997
Cyclin-dependent kinases and mitogen-activated protein kinases have been implicated in the regulation of cellular survival and apoptosis. We tested the effect of two mitogen-activated/cyclin-dependent kinase inhibitors, olomoucine and butyrolactone I, on
Marc A. Markus, Philipp J. Kahle, Andrea Winkler, Sonja Horstmann, Johanna M.H. Anneser, Gian Domenico Borasio   +5 more
doaj   +1 more source

Integrative network-centric approach reveals signaling pathways associated with plant resistance and susceptibility to Pseudomonas syringae.

PLoS Biology, 2018
Plant protein kinases form redundant signaling pathways to perceive microbial pathogens and activate immunity. Bacterial pathogens repress cellular immune responses by secreting effectors, some of which bind and inhibit multiple host kinases.
Elizabeth K Brauer, George V Popescu, Dharmendra K Singh, Mauricio Calviño, Kamala Gupta, Bhaskar Gupta, Suma Chakravarthy, Sorina C Popescu   +7 more
doaj   +1 more source

Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential

Biomolecules, 2021
Oximes have been studied for decades because of their significant roles as acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have been reported with useful pharmaceutical properties, including compounds with ...
Igor A. Schepetkin, Mark B. Plotnikov, Andrei I. Khlebnikov, Tatiana M. Plotnikova, Mark T. Quinn   +4 more
doaj   +1 more source

Harmine and 7,8-dihydroxyflavone synergistically suitable for amyotrophic lateral sclerosis management: An in silico study [PDF]

Research Results in Pharmacology, 2022
Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by progressive degeneration of both upper and lower motor neurons, resulting in paralysis and eventually leads to death from respiratory failure typically ...
Toluwase Fatoki, Stanley Chukwuejim, Omodele Ibraheem, Christiana Oke, Blessing Ejimadu, Isaiah Olaoye, Oluwabukola Oyegbenro, Taiwo Salami, Romilola Basorun, Oluwafisayomi Oluwadare, Yetunde Salawudeen   +10 more
doaj   +3 more sources

Death-associated Protein Kinase Is Activated by Dephosphorylation in Response to Cerebral Ischemia [PDF]

Journal of Biological Chemistry, 2005
Death-associated protein kinase (DAPK) is a calcium calmodulin-regulated serine/threonine protein kinase involved in ischemic neuronal death. In situ hybridization experiments show that DAPK mRNA expression is up-regulated in brain following a global ischemic insult and down-regulated in ischemic tissues after focal ischemia. DAPK is inactive in normal
Mehrdad, Shamloo, Liza, Soriano, Tadeusz, Wieloch, Karoly, Nikolich, Roman, Urfer, Donna, Oksenberg   +5 more
openaire   +2 more sources

Idiopathic pulmonary fibrosis: Pathophysiology, cellular signaling, diagnostic and therapeutic approaches

Medicine in Drug Discovery, 2023
Idiopathic pulmonary fibrosis (IPF) is a life-threatening and progressive interstitial lung disease. Healthy pulmonary tissues were replaced by an altered extracellular matrix (ECM) and destroyed the alveolar architecture, which led to the disruption of ...
Ilma Shakeel, Mohammad Afzal, Asimul Islam, Sukhwinder Singh Sohal, Md. Imtaiyaz Hassan   +4 more
doaj   +1 more source

A multi-omics approach identifies key hubs associated with cell type-specific responses of airway epithelial cells to staphylococcal alpha-toxin. [PDF]

PLoS ONE, 2015
Responsiveness of cells to alpha-toxin (Hla) from Staphylococcus aureus appears to occur in a cell-type dependent manner. Here, we compare two human bronchial epithelial cell lines, i.e.
Erik Richter, Manuela Harms, Katharina Ventz, Philipp Gierok, Ravi Kumar Chilukoti, Jan-Peter Hildebrandt, Jörg Mostertz, Falko Hochgräfe   +7 more
doaj   +1 more source

Death‐associated protein kinase (DAPK) and signal transduction: regulation in cancer [PDF]

The FEBS Journal, 2009
Death‐associated protein kinase (DAPK) is a pro‐apoptotic serine/threonine protein kinase that is dysregulated in a wide variety of cancers. The mechanism by which this occurs has largely been attributed to promoter hypermethylation, which results in gene silencing.
Alison M, Michie, Alison M, McCaig, Rinako, Nakagawa, Milica, Vukovic   +3 more
openaire   +2 more sources

Mechanism of activation of NDR protein kinase by the HMOB1 protein [PDF]

, 2005
Serine/threonine kinases of the nuclear Dbf2-related (NDR) family are highly conserved throughout the eukaryotic world. Members of this kinase family are implicated in various aspects of the regulation of cell division and cell morphology. It has been
Bichsel, Samuel J.
core   +1 more source