Regulatory Non-coding RNAs for Death Associated Protein Kinase Family [PDF]
Frontiers in Molecular Biosciences, 2021 The death associated protein kinases (DAPKs) are a family of calcium dependent serine/threonine kinases initially identified in the regulation of apoptosis. Previous studies showed that DAPK family members, including DAPK1, DAPK2 and DAPK3 play a crucial regulatory role in malignant tumor development, in terms of cell apoptosis, proliferation, invasion
Qingshui Wang +6 more
openaire +3 more sources
DAPK1 (death-associated protein kinase 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on DAPK1 (death-associated protein kinase 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Schneider-Stock, R +2 more
openaire +2 more sources
DAPK2 (death-associated protein kinase 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 Short communication on DAPK2, with data on DNA and on the protein encoded.
Pinto, Mafalda, Maximo, Valdemar
openaire +2 more sources
Antisense Depletion of Death-associated Protein Kinase Promotes Apoptosis [PDF]
Journal of Biological Chemistry, 2003 Death-associated protein kinases (DAPK) are serine/threonine protein kinases that have an important role in regulating cell death. In this study two antisense approaches were employed to down-regulate expression of the endogenous DAPK-alpha and DAPK-beta proteins.
Yijun, Jin, Patricia J, Gallagher
openaire +2 more sources
p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]
, 2005 In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Sambo, Anne-Véronique +15 more
core +1 more source
Death‐associated protein kinase (DAPK) and signal transduction: regulation in cancer [PDF]
The FEBS Journal, 2009 Death‐associated protein kinase (DAPK) is a pro‐apoptotic serine/threonine protein kinase that is dysregulated in a wide variety of cancers. The mechanism by which this occurs has largely been attributed to promoter hypermethylation, which results in gene silencing.
Alison M, Michie +3 more
openaire +2 more sources
C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis [PDF]
, 2003 Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription ...
Brugg, B. +4 more
core +1 more source
Functional characterization of human NDR kinases : novel regulatory mechanisms and a path towards direct substrates [PDF]
, 2012 Protein kinases are important regulators of signal transduction pathways in both unicellular and multicellular organisms. They play critical roles in biological processes such as cell growth, division, differentiation, adhesion, motility and cell death ...
Kohler, Reto
core +1 more source
Structural insight into nucleotide recognition by human death-associated protein kinase [PDF]
Acta Crystallographica Section D Biological Crystallography, 2009 Death-associated protein kinase (DAPK) is a member of the Ca(2+)/calmodulin-regulated family of serine/threonine protein kinases. The role of the kinase activity of DAPK in eukaryotic cell apoptosis and the ability of bioavailable DAPK inhibitors to rescue neuronal death after brain injury have made it a drug-discovery target for neurodegenerative ...
McNamara, Laurie K. +2 more
openaire +2 more sources
SnRK2 Protein Kinases-Key Regulators of Plant Response to Abiotic Stresses [PDF]
, 2011 The SnRK2 family members are plant-specific serine/threonine kinases involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development.
Wawer, Izabela +9 more
core +1 more source