Biomedicines, 2017 Targeted cancer immunotherapy is designed to selectively eliminate tumor cells without harming the surrounding healthy tissues. The death-associated protein kinases (DAPk) are a family of proapoptotic proteins that play a vital role in the regulation of ...
Mehmet Kemal Tur +5 more
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ROCK Inhibition as Potential Target for Treatment of Pulmonary Hypertension
Cells, 2021 Pulmonary hypertension (PH) is a cardiovascular disease caused by extensive vascular remodeling in the lungs, which ultimately leads to death in consequence of right ventricle (RV) failure.
Tadeu L. Montagnoli +6 more
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Modulation of neuronal survival factor MEF2 by kinases in Parkinson’s disease
Frontiers in Physiology, 2012 Parkinson’s disease (PD) is the second most common neurodegenerative disorder due to selective death of neurons in the substantia nigra pars compacta (SNpc). The cause of cell death remains largely unknown.
Yue eYin +6 more
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Mammalian NDR kinases : tumor suppressors with essential functions in embryonic development [PDF]
, 2011 NDR kinases are highly conserved from yeast to man. Loss-of-function models of Ndr homologs in yeast and fly demonstrate essential functions of the respective kinases.
Schmitz-Rohmer, Debora
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Death Associated Protein Kinase 1 (DAPK1): A Regulator of Apoptosis and Autophagy [PDF]
Frontiers in Molecular Neuroscience, 2016 Death-Associated Protein Kinase 1 (DAPK1) belongs to a family of five serine/threonine (Ser/Thr) kinases that possess tumor suppressive function and also mediate a wide range of cellular processes, including apoptosis and autophagy. The loss and gain-of-function of DAPK1 is associated with various cancer and neurodegenerative diseases respectively.
Singh, Pratibha +2 more
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The role of BRI1-associated kinase 1 (BAK1) in the regulation of plant innate immunity : functional and genetic characterization of BAK1 overexpression in Arabidopsis thaliana [PDF]
, 2014 The role of BRI1-ASSOCIATED KINASE 1 (BAK1) in the regulation of plant innate immunity: functional and genetic characterization of BAK1 overexpression in Arabidopsis thaliana SUMMARY BAK1 (BRI1-ASSOCIATED KINASE 1) is an intensively studied member ...
Kiss-Papp, Márta
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Biochemistry Research International, 2012 Anthracyclines remain the cornerstone of treatment in many malignancies but these agents have a cumulative dose relationship with cardiotoxicity. Development of cardiomyopathy and congestive heart failure induced by anthracyclines are typically dose ...
David Montaigne +2 more
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Developmental changes in distribution of death-associated protein kinase mRNAs
Journal of Neuroscience Research, 1999 Death-associated protein kinase (DAP-kinase) is Ca(2+)/calmodulin-dependent serine/threonine kinase that contains ankyrin repeats and the death domain. It has been isolated as a positive mediator of interferon-gamma-induced apoptotic cell death of HeLa cells.
M, Yamamoto +11 more
openaire +3 more sources
Molecular insights into the regulatory interactions of Dystrophia myotonica protein kinase [PDF]
, 2006 Dystrophia Myotonica Protein Kinase (DMPK) is the defining member of a family of complex, multidomain kinases of major biomedical relevance. These kinases are characterized by a highly conserved catalytic domain and a coiled-coil motif (CC) involved in ...
Garcia, Pilar
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The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage. [PDF]
PLoS ONE, 2011 Commonly used antitumor treatments, including radiation and chemotherapy, function by damaging the DNA of rapidly proliferating cells. However, resistance to these agents is a predominant clinical problem.
Melissa C Srougi, Keith Burridge
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