Results 31 to 40 of about 230,761 (264)

Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases

, 2009
Background: The c-Cbl-associated protein (CAP), also known as ponsin, localizes to focal adhesions and stress fibers and is involved in signaling events.
Tomasovic, Ana, Ana Tomasovic, Tikkanen Ritva, Fernow Inga, Inga Fernow, Siehoff-Icking, Ann, Fernow, Inga Susanne, Tikkanen, Ritva, Ann Siehoff-Icking, Tomasovic Ana, Siehoff-Icking Ann, Ritva Tikkanen   +11 more
core   +1 more source

Identification and Characterization of a Small‐Molecule Inhibitor of Death‐Associated Protein Kinase 1 [PDF]

ChemBioChem, 2014
A novel imidazo-pyramidazine inhibitor of DAPK1 that undergoes class-specific interactions and extends into the substrate recognition site has been identified. This inhibitor is a good starting point for the development of selective and potent inhibitors of DAPK1, with potential use against stroke and ischemia.
Wilbek, Theis S, Skovgaard, Tine, Sorrell, Fiona J, Knapp, Stefan, Berthelsen, Jens, Strømgaard, Kristian   +5 more
openaire   +4 more sources

Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase [PDF]

Oncogene, 2011
Death-associated protein kinase (DAPk), a multi-domain serine/threonine kinase, regulates numerous cell death mechanisms and harbors tumor suppressor functions. In this study, we report that DAPk directly binds and functionally activates pyruvate kinase M2 (PKM2), a key glycolytic enzyme, which contributes to the regulation of cancer cell metabolism ...
Mor, I., Carlessi, Rodrigo, Ast, T., Feinstein, E., Kimchi, A.   +4 more
openaire   +3 more sources

Expanding the Hippo pathway : hMOB3 modulates apoptotic MST1 signaling and supports tumor growth in glioblastoma [PDF]

, 2014
Protein kinases are critical players of signal transduction pathways involved in development, physiological and pathological processes. Deregulation of protein kinase signaling is found to be causal or related to varieties of human diseases, such as ...
Tang, Fengyuan
core   +1 more source

The role of HER1-HER4 and EGFRvIII in hormone-refractory prostate cancer [PDF]

, 2006
<b>Purpose</b>: The role of the type I receptor tyrosine kinase (HER) family in progression of prostate cancer is controversial. Breast cancer studies show that these receptors should be investigated as a family.
Traynor, P., Munro, A., Dunne, B., Edwards, J., Bartlett, J.M.S., Pirrett, C.F.   +5 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

DRAKs, Novel Serine/Threonine Kinases Related to Death-associated Protein Kinase That Trigger Apoptosis [PDF]

Journal of Biological Chemistry, 1998
The present study describes the cloning of two novel serine/threonine kinases termed DRAK1 and DRAK2, whose catalytic domains are related to that of death-associated protein kinase, a serine/threonine kinase involved in apoptosis. Both DRAKs are composed of the N-terminal catalytic domain and the C-terminal domain that is responsible for regulation of ...
H, Sanjo, T, Kawai, S, Akira
openaire   +2 more sources

Protein phosphorylation in yeast mitochondria [PDF]

, 1987
We describe the identification and submitochondrial localization of four protein kinases and of their target proteins in derepressed yeast mitochondria. The activity of one of the kinases depends on the presence of cyclic AMP (cAMP).
Günter Müller, Bandlow, Wolfhard, Wolfhard Bandlow, Müller, Günter   +3 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Regulation of spinach SNF1‐related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5′‐AMP

, 1999
Summary Members of the SNF1‐related protein kinase‐1 (SnRK1) subfamily of protein kinases are higher plant homologues of mammalian AMP‐activated and yeast SNF1 protein kinases.
Crawford, R. M., Hardie, D. G., Halford, N. G., Sugden, C.   +3 more
core   +1 more source