Results 51 to 60 of about 12,734,425 (305)

Regulation of Arabidopsis Matrix Metalloproteinases by Mitogen-Activated Protein Kinases and Their Function in Leaf Senescence

Frontiers in Plant Science, 2022
Leaf senescence is a developmentally programmed cell death process that is influenced by a variety of endogenous signals and environmental factors. Here, we report that MPK3 and MPK6, two Arabidopsis mitogen-activated protein kinases (MAPKs or MPKs), and
Hongjiao Wu, Qi Si, Jianmin Liu, Liuyi Yang, Shuqun Zhang, Juan Xu   +5 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation [PDF]

, 2013
Casein kinase 2 (protein kinase CK2) is a conserved eukaryotic serine/theronine kinase with multiple substrates and roles in the regulation of cellular processes such as cellular stress, cell proliferation and apoptosis.
Mahmood Alam, Schmid, Ralf, Alam, Mahmood M, Cullis, Paul M, Andrew B. Tobin (7589429), Lev Solyakov (122244), Solyakov, Lev, Andrew R Bottrill, Andrew B Tobin, G. Burley (7653734), Graciotti, Michele, Burley, Glenn, Lev Solyakov, Tobin, Andrew B., Bottrill, Andrew R, Mahmood Alam (540985), Andrew R. Bottrill, Andrew B. Tobin, Doerig, Christian D, Alam, Mahmood, Paul Cullis, Bottrill, Andrew, Paul Cullis (540988), Doerig, Christian, Michele Graciotti, Ralf Schmid (45614), Michele Graciotti (540984), Burley, Glenn Ashley, C. Doerig (7646465), Glenn Burley, Andrew R. Bottrill (540987), Tobin, Andrew, Christian Doerig, Bottrill, Andrew R., Tobin, Andrew B, Cullis, Paul, Ralf Schmid   +36 more
core   +3 more sources

Molecular Docking Studies of a Cyclic Octapeptide-Cyclosaplin from Sandalwood

Biomolecules, 2019
Natural products from plants, such as chemopreventive agents, attract huge attention because of their low toxicity and high specificity. The rational drug design in combination with structure-based modeling and rapid screening methods offer significant ...
Abheepsa Mishra, Satyahari Dey
doaj   +1 more source

DRAKs, Novel Serine/Threonine Kinases Related to Death-associated Protein Kinase That Trigger Apoptosis [PDF]

Journal of Biological Chemistry, 1998
The present study describes the cloning of two novel serine/threonine kinases termed DRAK1 and DRAK2, whose catalytic domains are related to that of death-associated protein kinase, a serine/threonine kinase involved in apoptosis. Both DRAKs are composed of the N-terminal catalytic domain and the C-terminal domain that is responsible for regulation of ...
H, Sanjo, T, Kawai, S, Akira
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Necroptosis in Cholangiocarcinoma

Cells, 2020
Necroptosis is a type of regulated cell death that is increasingly being recognized as a relevant pathway in different pathological conditions. Necroptosis can occur in response to multiple stimuli, is triggered by the activation of death receptors, and ...
Samantha Sarcognato, Iris E. M. de Jong, Luca Fabris, Massimiliano Cadamuro, Maria Guido   +4 more
doaj   +1 more source

Protein phosphorylation in yeast mitochondria [PDF]

, 1987
We describe the identification and submitochondrial localization of four protein kinases and of their target proteins in derepressed yeast mitochondria. The activity of one of the kinases depends on the presence of cyclic AMP (cAMP).
Günter Müller, Bandlow, Wolfhard, Wolfhard Bandlow, Müller, Günter   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death.

PLoS ONE, 2012
The Tumor Susceptibility Gene 101 (Tsg101) encodes a multi-domain protein that mediates a variety of molecular and biological processes including the trafficking and lysosomal degradation of cell surface receptors.
Chantey R Morris, Marissa J Stanton, Karoline C Manthey, Keon Bong Oh, Kay-Uwe Wagner   +4 more
doaj   +1 more source