Results 71 to 80 of about 12,734,425 (305)

Mediators of necroptosis: from cell death to metabolic regulation

EMBO Molecular Medicine
Necroptosis, a programmed cell death mechanism distinct from apoptosis, has garnered attention for its role in various pathological conditions.
Xiaoqin Wu, Laura E Nagy, Jérémie Gautheron   +2 more
doaj   +1 more source

Protein kinases as therapeutic targets for Alzheimer’s disease: a brief review

Exploration of Neuroprotective Therapy
Alzheimer’s disease (AD) is a progressive and incurable neurodegenerative disorder, with an unknown etiology and a multifactorial pathophysiology characterized by protein misfolding, neuroinflammation, and neuronal loss.
Isabela Marie Fernandes Silva, Graziella dos Reis Rosa Franco, Vanessa Silva Gontijo, Claudio Viegas Jr.   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Role of protease-activated receptor-2 on cell death and DNA fragmentation in Helicobacter pylori-infected gastric epithelial cells

Journal of Translational Medicine, 2010
Background Helicobacter pylori (H. pylori) infection is associated with chronic gastritis, peptic ulceration and gastric carcinoma. Protease-activated receptor-2 (PAR-2), which is activated by trypsin, induced the activation of mitogen-activated protein ...
Lim Joo, Kim Hyeyoung
doaj   +1 more source

New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform. [PDF]

PLoS ONE, 2011
DRP-1 and ZIPk are two members of the Death Associated Protein Ser/Thr Kinase (DAP-kinase) family, which function in different settings of cell death including autophagy. DAP kinases are very similar in their catalytic domains but differ substantially in
Yishay Shoval, Hanna Berissi, Adi Kimchi, Shmuel Pietrokovski   +3 more
doaj   +1 more source

The role of Hippo pathway in ferroptosis

Frontiers in Oncology, 2023
The role of Hippo pathway in ferroptosisThe Hippo pathway is mainly composed of mammalian serine/threonine (Ste20)like kinases 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and transcriptional coactivator Yes-associated protein (YAP), and is ...
Jiangxia Xiang, Mengmeng Jiang, Xing Du, Xing Du   +3 more
doaj   +1 more source

The role of HER1-HER4 and EGFRvIII in hormone-refractory prostate cancer [PDF]

, 2006
<b>Purpose</b>: The role of the type I receptor tyrosine kinase (HER) family in progression of prostate cancer is controversial. Breast cancer studies show that these receptors should be investigated as a family.
Traynor, P., Munro, A., Dunne, B., Edwards, J., Bartlett, J.M.S., Pirrett, C.F.   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Death‐associated protein kinase 3 regulates the myogenic reactivity of cerebral arteries

Experimental Physiology, 2023
AbstractThe vascular smooth muscle (VSM) of resistance blood vessels is a target of intrinsic autoregulatory responses to increased intraluminal pressure, the myogenic response. In the brain, the myogenic reactivity of cerebral arteries is critical to homeostatic blood flow regulation.
Sara R. Turner, Abdulhameed Al‐Ghabkari, David A. Carlson, Mona Chappellaz, Cindy Sutherland, Timothy A. J. Haystead, William C. Cole, Justin A. MacDonald   +7 more
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source