Results 41 to 50 of about 12,734,425 (305)

Structural insight into nucleotide recognition by human death-associated protein kinase [PDF]

Acta Crystallographica Section D Biological Crystallography, 2009
Death-associated protein kinase (DAPK) is a member of the Ca(2+)/calmodulin-regulated family of serine/threonine protein kinases. The role of the kinase activity of DAPK in eukaryotic cell apoptosis and the ability of bioavailable DAPK inhibitors to rescue neuronal death after brain injury have made it a drug-discovery target for neurodegenerative ...
McNamara, Laurie K., Watterson, D. Martin, Brunzelle, Joseph S.   +2 more
openaire   +2 more sources

JNK and ERK8 as downstream effectors of receptor tyrosine kinases [PDF]

, 2006
MAP kinases are a super-family of serine-threonine protein kinases expressed in all eukaryotic cells. In mammals, there are many MAP kinases with different biological functions, grouped in distinctly regulated groups, ERK1/2 (extracellular signal related
Iavarone, Carlo
core   +1 more source

Death-Associated Protein Kinase-Related Protein 1, a Novel Serine/Threonine Kinase Involved in Apoptosis [PDF]

Molecular and Cellular Biology, 2000
In this study we describe the identification and structure-function analysis of a novel death-associated protein (DAP) kinase-related protein, DRP-1. DRP-1 is a 42-kDa Ca(2+)/calmodulin (CaM)-regulated serine threonine kinase which shows high degree of homology to DAP kinase.
B, Inbal, G, Shani, O, Cohen, J L, Kissil, A, Kimchi   +4 more
openaire   +2 more sources

Magnaporthe oryzae-Secreted Protein MSP1 Induces Cell Death and Elicits Defense Responses in Rice

Molecular Plant-Microbe Interactions, 2016
The Magnaporthe oryzae snodprot1 homolog (MSP1), secreted by M. oryzae, is a cerato-platanin family protein. msp1-knockout mutants have reduced virulence on barley leaves, indicating that MSP1 is required for the pathogenicity of rice blast fungus.
Yiming Wang, Jingni Wu, Sang Gon Kim, Kenichi Tsuda, Ravi Gupta, Sook-Young Park, Sun Tae Kim, Kyu Young Kang   +7 more
doaj   +1 more source

Plasmalogens rescue neuronal cell death through an activation of AKT and ERK survival signaling. [PDF]

PLoS ONE, 2013
Neuronal cells are susceptible to many stresses, which will cause the apoptosis and neurodegenerative diseases. The precise molecular mechanism behind the neuronal protection against these apoptotic stimuli is necessary for drug discovery. In the present
Md Shamim Hossain, Masataka Ifuku, Sachiko Take, Jun Kawamura, Kiyotaka Miake, Toshihiko Katafuchi   +5 more
doaj   +1 more source

Exploring downstream pathways of aberrantly activated kinases for targeted leukemia therapy [PDF]

, 2008
Genetic alterations resulting in uncontrolled protein tyrosine kinases (PTKs) activity are frequently found in leukemia and in human solid cancers. Although the development of small molecule kinase inhibitors has revolutionized therapy for PTKinduced ...
Gasser, Christelle
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer. [PDF]

Mol Oncol
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Kim A, Aslam M, Torruella E, Sony A, Rahman A, Smith S, de la Parra C, Sauane M.   +7 more
europepmc   +2 more sources

Identification and Characterization of a Small‐Molecule Inhibitor of Death‐Associated Protein Kinase 1 [PDF]

ChemBioChem, 2014
A novel imidazo-pyramidazine inhibitor of DAPK1 that undergoes class-specific interactions and extends into the substrate recognition site has been identified. This inhibitor is a good starting point for the development of selective and potent inhibitors of DAPK1, with potential use against stroke and ischemia.
Wilbek, Theis S, Skovgaard, Tine, Sorrell, Fiona J, Knapp, Stefan, Berthelsen, Jens, Strømgaard, Kristian   +5 more
openaire   +4 more sources

Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase [PDF]

Oncogene, 2011
Death-associated protein kinase (DAPk), a multi-domain serine/threonine kinase, regulates numerous cell death mechanisms and harbors tumor suppressor functions. In this study, we report that DAPk directly binds and functionally activates pyruvate kinase M2 (PKM2), a key glycolytic enzyme, which contributes to the regulation of cancer cell metabolism ...
Mor, I., Carlessi, Rodrigo, Ast, T., Feinstein, E., Kimchi, A.   +4 more
openaire   +3 more sources

Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo [PDF]

, 2004
<b>Background</b> From in vitro studies, it has become clear that several signaling cascades are involved in angiotensin II-induced cellular hypertrophy.
Martens Fabrice MAC, Fabrice MAC Martens, Touyz, R.M., Daigle, Christine, Martens, Fabrice, Touyz Rhian M, Dao Huy, Christine Daigle, Huy Hao Dao, Daphné Girardot, Rhian M Touyz, Moreau Pierre, Girardot, D., Daigle, C., Dao, H., Moreau, P., Girardot, Daphné, Martens, F.M.A.C., Dao, Huy, Daigle Christine, Moreau, Pierre, Girardot Daphné, Pierre Moreau, Touyz, Rhian   +23 more
core   +2 more sources