Results 111 to 120 of about 1,789 (171)

Microbicide Vaginal Rings: Technological Challenges and Clinical Development [PDF]

, 2016
Boyd, Peter J., Malcolm, R. Karl, McCoy, Clare F., Murphy, Diarmaid J.   +3 more
core   +1 more source

Dapivirine Levonorgestrel Vaginal Ring: A multipurpose prevention ring for HIV and contraceptive protection [PDF]

Leveraging our experience developing the monthly dapivirine vaginal ring (DVR or “PrEP ring”), which received a positive opinion from the European Medicines Agency in 2020 for women’s HIV risk reduction, the Population Council is developing a 3-month ...
IPM South Africa
core   +1 more source

Counterfactual Groups to Assess Vaccine or Treatment Efficacy in HIV Prevention Trials in High-Risk Populations in Uganda

Vaccines
Background: Assessment of efficacy in HIV prevention trials remains a challenge in the era of widespread use of active controls. We investigated use of counterfactual groups to assess treatment efficacy.
Andrew Abaasa, Yunia Mayanja, Zacchaeus Anywaine, Sylvia Kusemererwa, Eugene Ruzagira, Pontiano Kaleebu   +5 more
doaj   +1 more source

Intravaginal immunization using a novel antigen-releasing ring device elicits robust vaccine antigen-specific systemic and mucosal humoral immune responses [PDF]

, 2017
Aldon, Yoann, Kett, Vicky, King, Deborah, Malcolm, R Karl, Mann, Jamie F S, McKay, Paul F, Pattani, Aditya, Shattock, Robin J   +7 more
core   +1 more source

Acceptability and Use of the Dapivirine Vaginal Ring and Daily Oral Pre-exposure Prophylaxis (PrEP) During Breastfeeding in South Africa, Malawi, Zimbabwe, and Uganda. [PDF]

AIDS Behav, 2023
Stoner MCD, Hawley I, Mathebula F, Horne E, Etima J, Kemigisha D, Mutero P, Dandadzi A, Seyama L, Fabiano Z, Scheckter R, Noguchi L, Owor M, Balkus JE, Montgomery ET.   +14 more
europepmc   +1 more source

Doctor of Philosophy [PDF]

, 2015
dissertationOver three decades have passed since the discovery of human immunodeficiency virus (HIV), and with no viable vaccine, new technologies to prevent the spread of the virus are urgently needed. Pre-exposure prophylaxis, the concept of chemically
Teller, Ryan Stevenson
core  

Clinical Presentation, Treatment Response, and Virology Outcomes of Women Who Seroconverted in the Dapivirine Vaginal Ring Trials-The Ring Study and DREAM. [PDF]

Clin Infect Dis, 2023
Steytler J, van der Ryst E, Craig C, Van Baelen B, Nuttall J, van Niekerk N, Mellors J, Parikh U, Wallis C, IPM 007 Study Team.   +9 more
europepmc   +1 more source

Pharmacokinetics and Safety Assessment of Anti-HIV Dapivirine Vaginal Microbicide Rings with Multiple Dosing

, 2020
Objectives: Self-administered vaginal rings are a promising method for delivery of topical anti-HIV microbicidesand might offer an adherence advantage over daily or coitally-dependent dosage forms such as gels. This trialassessed the safety and pharmacokinetic aspects of the Dapivirine Vaginal Ring-004 when worn as multiple rings oversequential periods
openaire   +2 more sources

Clinical use of vaginal or rectally applied microbicides in patients suffering from HIV/AIDS

HIV/AIDS: Research and Palliative Care, 2013
Satish Kumar Gupta, Nutan Reproductive Cell Biology Laboratory, National Institute of Immunology, New Delhi, India Abstract: Microbicides, primarily used as topical pre-exposure prophylaxis, have been proposed to prevent sexual transmission of HIV.
Gupta SK, Nutan
doaj  

Efficacy and Action of the Dapivirine Vaginal Ring as Understood by Women Participating in an Open Label Extension Study. [PDF]

AIDS Behav, 2023
Naidoo K, T ME, Katz AW, Morgan G, Krishnaveni R, Lydia ST, Sarita N, Leila ME.   +7 more
europepmc   +1 more source