Results 51 to 60 of about 1,789 (171)

The cost-effectiveness of multi-purpose HIV and pregnancy prevention technologies in South Africa. [PDF]

, 2018
INTRODUCTION: A number of antiretroviral HIV prevention products are efficacious in preventing HIV infection. However, the sexual and reproductive health needs of many women extend beyond HIV prevention, and research is ongoing to develop multi-purpose ...
Cabrera Escobar, Maria A, Delany-Moretlwe, Sinead, Eakle, Robyn, Kilbourne-Brook, Maggie, Meyer-Rath, Gesine, Mvundura, Mercy, Quaife, Matthew, Terris-Prestholt, Fern, Vickerman, Peter   +8 more
core   +1 more source

First Impressions Matter: How Initial Worries Influence Adherence to the Dapivirine Vaginal Ring. [PDF]

J Acquir Immune Defic Syndr, 2019
Background: In MTN-020/ASPIRE, a dapivirine vaginal ring effectiveness trial in sub-Saharan Africa, we assessed whether worries about ring use changed over time and were associated with adherence. Methods: Participants (N = 2585) were surveyed at baseline and follow-up about worries
van der Straten A, Browne EN, Shapley-Quinn MK, Brown ER, Reddy K, Scheckter R, Soto-Torres L, Palanee-Phillips T, Baeten JM, Mensch B, MTN-020/ASPIRE Study Team.   +10 more
europepmc   +4 more sources

Clinical testing of antiretroviral drugs as future prevention against vaginal and rectal transmission of HIV infection – a review of currently available results

Acta Pharmaceutica, 2019
The original purpose of vaginally applied microbicides was to slow down the HIV epidemic among the population until an effective vaccination was developed.
Vysloužil Jakub, Kubová Kateřina, Tkadlečková Veronika Nováková, Vetchý David   +3 more
doaj   +1 more source

The influence of social constructs of hegemonic masculinity and sexual behaviour on acceptability of vaginal microbicides in Zambia [PDF]

, 2017
Vaginal microbicides are heralded as a woman’s HIV prevention method. This ethnographic study, conducted in a trial setting in Zambia, explored how the social construction of masculinity and sexual behaviour influenced the acceptability of vaginal ...
Bond, V, Dixey, R, Mweemba, O, White, AK
core   +2 more sources

Investigating the Contribution of Drug-Metabolizing Enzymes in Drug-Drug Interactions of Dapivirine and Miconazole

Pharmaceutics, 2021
Dapivirine (DPV) is a potent NNRTI used to prevent the sexual transmission of HIV. In a phase 1 trial (IPM 028), the concomitant use of a DPV vaginal ring and an antifungal miconazole (MIC) vaginal capsule was found to increase the systemic exposure to ...
Guru Raghavendra Valicherla, Phillip Graebing, Junmei Zhang, Ruohui Zheng, Jeremy Nuttall, Peter Silvera, Lisa Cencia Rohan   +6 more
doaj   +1 more source

Pre-exposure prophylaxis (PrEP) in an era of stalled HIV prevention: Can it change the game? [PDF]

, 2018
Pre-exposure prophylaxis (PrEP) for HIV prevention has evolved significantly over the years where clinical trials have now demonstrated the efficacy of oral PrEP, and the field is scaling-up implementation.
Eakle, Robyn, Rees, Helen, Venter, Francois   +2 more
core   +1 more source

Phase 1 pharmacokinetics and safety study of extended duration dapivirine vaginal rings in the United States [PDF]

Journal of the International AIDS Society, 2021
AbstractIntroductionVaginal rings are a promising approach to provide a woman‐centred, long‐acting HIV prevention strategy. Prior trials of a 25 mg dapivirine (DPV) ring have shown a favourable safety profile and approximately 30% risk reduction of HIV‐1 infection.
Albert Y Liu, Clara Dominguez Islas, Holly Gundacker, Blazej Neradilek, Craig Hoesley, Ariane van der Straten, Craig W Hendrix, May Beamer, Cindy E Jacobson, Tara McClure, Tanya Harrell, Katherine Bunge, Brid Devlin, Jeremy Nuttall, Patrick Spence, John Steytler, Jeanna M Piper, Mark A Marzinke   +17 more
openaire   +2 more sources

Efficient regulatory approval of two novel HIV prevention interventions in a resource-limited setting: experiences from Zimbabwe

Frontiers in Reproductive Health, 2023
The global burden of HIV remains unacceptably high despite significant progress made in HIV treatment and prevention. There is an urgent need to scale up the comprehensive HIV prevention strategies that include pre-exposure prophylaxis (PrEP).
Caroline Murombedzi, Libert Chirinda, Gift T. Chareka, Z. Mike Chirenje, Nyaradzo M. Mgodi   +4 more
doaj   +1 more source

Preferences for ARV-based HIV prevention methods among men and women, adolescent girls and female sex workers in Gauteng Province, South Africa: a protocol for a discrete choice experiment. [PDF]

, 2016
INTRODUCTION: For the past few decades, condoms have been the main method of HIV prevention. Recent advances in antiretroviral (ARV)-based prevention products have substantially changed the prevention landscape, yet little is known about how popular ...
Cabrera, Maria, Cianci, Fiona, Delany-Moretlwe, Sinead, Eakle, Robyn, Quaife, Matthew, Terris-Prestholt, Fern, Tsepe, Motlalepule, Vickerman, Peter   +7 more
core   +3 more sources

Vaginal contraception: a roadmap to women's reproductive autonomy-a narrative review [PDF]

, 2023
The right to contraception information and services is one of the essential rights of every woman that guarantees access to safe, acceptable, available, and good-quality contraceptives.
Kumar, Naina
core   +2 more sources