Results 61 to 70 of about 1,789 (171)

Evaluation of polycaprolactone matrices for the intravaginal delivery of metronidazole in the treatment of bacterial vaginosis [PDF]

, 2014
Microporous, poly (ε-caprolactone) (PCL) matrices loaded with the antibacterial, metronidazole were produced by rapidly cooling suspensions of drug powder in PCL solutions in acetone. Drug incorporation in the matrices increased from 2.0% to 10.6% w/w on
Coombes, Allan G. A., Palmer, Cheryn, Pathak, Meenakshi, Turner, Mark   +3 more
core   +1 more source

Inhibition of HIV virus by neutralizing Vhh attached to dual functional liposomes encapsulating dapivirine [PDF]

, 2016
Although highly active antiretroviral therapy (HAART) has greatly improved the life expectancy of HIV/AIDS patients, the treatment is not curative.
AF Labrijn, AK Bhatia, BR Starcich, DC Chan, DF Gaddy, DS Watson, E Chertova, EO Freed, G Ofek, GNC Chiu, Guido Vanham, HL Wong, Ivan Roitt, J Cunha Da, J das Neves, J Icenogle, J Liu, Johan Michiels, JP Moore, JS Klein, JS Klein, Kevin K. Ariën, KV1 Rao, L Nieba, LE McCoy, M-Y Zhang, NK Malavia, P Zhu, P Zhu, PD Kwong, PD Kwong, R Clayton, R Duncan, R Wyatt, R Wyatt, RL Shew, Roger New, S Oliveira, Scarlet Xiaoyan Wang, SP Layne, TJ Smith, WWL Koh, X Wei, X Yu   +43 more
core   +1 more source

Acceptability of a dapivirine levonorgestrel vaginal ring in two Phase 1 trials (MTN-030/IPM 041 and MTN-044/IPM 053/CCN019): Implications for multipurpose prevention technology development.

PLoS ONE
End-user feedback early in product development is important for optimizing multipurpose prevention technologies for HIV and pregnancy prevention. We evaluated the acceptability of the 90-day dapivirine levonorgestrel ring (DPV-LNG ring) used for 14 days ...
Barbara A Friedland, Holly Gundacker, Sharon L Achilles, Beatrice A Chen, Craig Hoesley, Barbra A Richardson, Clifton W Kelly, Jeanna Piper, Sherri Johnson, Brid Devlin, John Steytler, Kyle Kleinbeck, Bindi Dangi, Chantél Friend, Mei Song, Barbara Mensch, Ariane van der Straten, Cindy Jacobson, Craig W Hendrix, Jill Brown, Diana Blithe, Sharon L Hiller, MTN-030/IPM 041 and MTN-044/IPM 053/CCN019 Protocol Teams for the Microbicide Trials Network and the Contraceptive Clinical Trials Network   +22 more
doaj   +2 more sources

“Male-supported, female-initiated”

Communicare, 2022
HIV and AIDS remain one of the leading public health challenges in the world, with young women in sub-Saharan Africa bearing the brunt of HIV infection.
Eliza Govender, Yonela Vukapi, Phiwe Nota   +2 more
doaj   +1 more source

Phase 2a Safety, Pharmacokinetics, and Acceptability of Dapivirine Vaginal Rings in US Postmenopausal Women [PDF]

Clinical Infectious Diseases, 2018
Postmenopausal women have unique sociobiological human immunodeficiency virus (HIV) risks. We evaluated the safety, pharmacokinetics, and acceptability of a microbicide dapivirine (DPV) vaginal ring (VR) versus placebo in postmenopausal women.We enrolled 96 HIV-negative postmenopausal US women in a phase 2a double-blind, randomized (3:1) trial of ...
Beatrice A Chen, Jingyang Zhang, Holly M Gundacker, Craig W Hendrix, Craig J Hoesley, Robert A Salata, Charlene S Dezzutti, Ariane van der Straten, Wayne B Hall, Cindy E Jacobson, Sherri Johnson, Ian McGowan, Annalene M Nel, Lydia Soto-Torres, Mark A Marzinke, B A Chen, C J Hoesley, B A Chen, R A Salata   +18 more
openaire   +2 more sources

Assessing Per-Sex-Act HIV-1 Risk Reduction Among Women Using the Dapivirine Vaginal Ring. [PDF]

J Infect Dis, 2023
Abstract Background Confounding introduced by individuals’ sexual risk behavior is potentially a significant source of bias in HIV-1 prevention intervention studies. To more completely account for sexual behaviors when assessing the efficacy of the monthly dapivirine ring, a new longer-acting HIV-1 ...
Stalter RM, Dong TQ, Hendrix CW, Palanee-Phillips T, van der Straten A, Hillier SL, Kiweewa FM, Mgodi NM, Marzinke MA, Bekker LG, Soto-Torres L, Baeten JM, Brown ER, MTN-020/ASPIRE Study Team.   +13 more
europepmc   +3 more sources

Bacterial biofilms in the vagina [PDF]

, 2017
A bacterial biofilm is a structured community of bacteria in a self-produced extracellular matrix, adherent to an inert surface or biological tissue. The involvement of biofilm in a bacterial infection implies that the infection is difficult to treat and
Cerca, Nuno, Crucitti, Tania, Hardy, Liselotte, Jespers, Vicky, Vaneechoutte, Mario   +4 more
core   +1 more source

Preferences and acceptability for long‐acting PrEP agents among pregnant and postpartum women with experience using daily oral PrEP in South Africa and Kenya

Journal of the International AIDS Society, 2023
Introduction Long‐acting pre‐exposure prophylaxis (PrEP) options could overcome barriers to oral PrEP persistence during pregnancy and postpartum. We evaluated long‐acting PrEP preferences among oral PrEP‐experienced pregnant and postpartum women in ...
Nafisa J. Wara, Rufaro Mvududu, Mary M. Marwa, Laurén Gómez, Nyiko Mashele, Catherine Orrell, Corrina Moucheraud, John Kinuthia, Grace John‐Stewart, Landon Myer, Risa Hoffman, Jillian Pintye, Dvora L. Joseph Davey   +12 more
doaj   +1 more source

Dapivirine vaginal ring for HIV prevention: modelling health outcomes, drug resistance and cost-effectiveness. [PDF]

J Int AIDS Soc, 2019
AbstractIntroductionA vaginal ring containing dapivirine is effective for HIV prevention as pre‐exposure prophylaxis (PrEP). We evaluated the potential epidemiological impact and cost‐effectiveness of dapivirine vaginal ring PrEP among 22‐ to 45‐year‐old women in KwaZulu‐Natal, South Africa.MethodsUsing mathematical modelling, we studied dapivirine ...
Glaubius R, Ding Y, Penrose KJ, Hood G, Engquist E, Mellors JW, Parikh UM, Abbas UL.   +7 more
europepmc   +4 more sources

Rationale and safety assessment of a novel intravaginal drug-delivery system with sustained DL-lactic acid release, intended for long-term protection of the vaginal microbiome [PDF]

, 2016
Bacterial vaginosis is a prevalent state of dysbiosis of the vaginal microbiota with wide-ranging impact on human reproductive health. Based on recent insights in community ecology of the vaginal microbiome, we hypothesize that sustained vaginal DL ...
Remon, Jean Paul, Verstraelen, Hans, Vervaet, Chris   +2 more
core   +4 more sources