Darier Disease with Psoriasis [PDF]
Medicina, 2022 Darier disease is an autosomal dominant disorder with dark crusty patches and is classified as hereditary acantholytic dermatosis. Keratotic papules and crust are often present on the scalp, forehead, chest, back, upper arms, elbows, groin, and behind ...
Seok-Young Kang +6 more
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Darier Disease – A Multi-organ Condition? [PDF]
Acta Dermato-Venereologica, 2021 Darier disease is a severe, rare autosomal dominant inherited skin condition caused by mutations in the ATP2A2 gene encoding sarcoendoplasmic reticulum Ca2+-ATPase isoform 2 in the endoplasmic reticulum.
Etty Bachar-Wikström +1 more
doaj +2 more sources
Mimicking Darier Disease In Vitro: A Human Epidermal Organoid Approach. [PDF]
Exp DermatolABSTRACT Darier disease (DD) is a rare genetic disorder caused by mutations in the ATP2A2 gene, resulting in calcium dysregulation and impaired keratinocyte adhesion. Due to the paucity of suitable models, understanding the molecular mechanisms of DD has been challenging.
Agarwal R +11 more
europepmc +2 more sources
Increased activation of ErbB and NF-κB signalling pathways in Darier disease affected skin. [PDF]
J Eur Acad Dermatol VenereolJournal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 506-509, March 2026.
Ernst N, Ludwig RJ, Vorobyev A.
europepmc +2 more sources
Darier disease: the use of dermoscopy in monitoring acitretin treatment [PDF]
Anais Brasileiros de Dermatologia, 2022 Darier disease is an uncommon autosomal dominant inherited disease, caused by a mutation in the ATP2A2 gene. The clinical findings are hyperkeratotic papules on the trunk, scalp, face, and neck, maceration of intertriginous areas, palmar pits, whitish ...
Catalina Silva-Hirschberg +3 more
doaj +2 more sources
Diagnosis and management of vulvar Darier disease: A case report [PDF]
Case Reports in Women's Health, 2023 Darier disease is an autosomal dominant disorder with hyperkeratotic papules affecting primarily seborrheic areas of the upper chest, back, forehead, scalp, nasolabial folds, ears, and, less frequently, the oral mucosa.
Ipek Evruke +3 more
doaj +2 more sources
Patients with Darier disease have an increased risk of keratinocyte carcinoma: a Swedish registry-based nationwide cohort study [PDF]
Orphanet Journal of Rare DiseasesBackground Darier disease is a genodermatosis which manifests as hyperkeratotic papules and superficial erosions mainly in seborrheic skin areas. This retrospective registry-based cohort study aimed to estimate the association between Darier disease and ...
Rahime Inci +4 more
doaj +2 more sources
Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease [PDF]
JCI Insight, 2023 Mutation of the ATP2A2 gene encoding sarco-endoplasmic reticulum calcium ATPase 2 (SERCA2) was linked to Darier disease more than 2 decades ago; however, there remain no targeted therapies for this disorder causing recurrent skin blistering and ...
Shivam A. Zaver +7 more
doaj +2 more sources
Beyond the skin involvement in Darier disease: A complicated neuropsychiatric phenotype [PDF]
Clinical Case Reports, 2021 Psichiatric illness such as depression, schizophrenia and cognitive deficiency are frequently associated with the Darier Disease. Physicians should be aware of such association to allow prompt diagnosis and early interventions of potentially life ...
Federica Li Pomi +7 more
doaj +2 more sources
Darier disease: a case report [PDF]
British Journal of Oral and Maxillofacial Surgery, 2005 Darier disease, also known as keratosis follicularis, dyskeratosis follicularis, and benign dyskeratosis, is a rare disorder of keratinisation that primarily affects the skin and, to a lesser extent, the oral mucosa. It was described independently by both Darier and White in 1889.
Jalil, A.A. +2 more
exaly +5 more sources