Results 61 to 70 of about 185,847 (298)

Acute hyperglycemia compromises the responses of choroidal vessels using swept-source optical coherence tomography during dark and light adaptations

Frontiers in Endocrinology, 2023
PurposeTo clarify the effects of acute hyperglycemia on the responses of choroidal structural components and vascularity index during light modulation in healthy participants using techniques including image binarization and artificial intelligence (AI ...
Zhiyang Lin, Huankai Yu, Huankai Yu, Ce Shi, Hongling Chen, Guangqing Lin, Meixiao Shen, Meixiao Shen, Chenxiao Wang   +8 more
doaj   +1 more source

Dark adaptation in vertebrate photoreceptors

Trends in Neurosciences, 1996
Exposure of the eye to bright light bleaches a significant fraction of the photopigment in rods and cones and produces a prolonged decrease in the sensitivity of vision, which recovers slowly as the photopigment is regenerated. This sensitivity decrease is larger than would be expected merely from the decrease in the concentration of the pigment ...
G L, Fain, H R, Matthews, M C, Cornwall
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Adaptation from Leaps in the Dark [PDF]

Journal of Heredity, 2008
Although many adaptations occur by selection of beneficial alleles transformed from neutral or deleterious standing variation, new identical mutant alleles that arise as premeiotic clusters have an increased probability of fixation that can rise to the levels that are similar to the fixation of standing variation.
Woodruff, Ronny C., Zhang, M
openaire   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Modeling light adaptation in circadian clock: prediction of the response that stabilizes entrainment.

PLoS ONE, 2011
Periods of biological clocks are close to but often different from the rotation period of the earth. Thus, the clocks of organisms must be adjusted to synchronize with day-night cycles. The primary signal that adjusts the clocks is light.
Kunichika Tsumoto, Gen Kurosawa, Tetsuya Yoshinaga, Kazuyuki Aihara   +3 more
doaj   +1 more source

DARK ADAPTATION AND THE DARK GROWTH RESPONSE OF PHYCOMYCES [PDF]

Journal of General Physiology, 1932
Light-adapted sporangiophores of the fungus Phycomyces respond to sudden darkening by a temporary decrease in the rate of elongation, after a latent period of several minutes. The reaction time of this "dark growth" response is compound like that of the "light growth" response. It is, moreover, shorter the more intense the previous illumination.
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Bio-Inspired Dark Adaptive Nighttime Object Detection

Biomimetics
Nighttime object detection is challenging due to dim, uneven lighting. The IIHS research conducted in 2022 shows that pedestrian anti-collision systems are less effective at night.
Kuo-Feng Hung, Kang-Ping Lin
doaj   +1 more source

Effects of Prolonged Dark Adaptation on Autokinetic Movement

, 1973
To determine the effects of prolonged dark adaptation on autokinetic movement 2 groups of 10 Ss with equal numbers of men and women were subjected to 1 hr. or 5 min. of dark adaptation before tests on autokinetic judgments. Ss dark adapted for 1 hr. had
Roger Clayton White
core   +1 more source